PMID: 8986775Dec 24, 1996Paper

Effect of beta-amyloid block of the fast-inactivating K+ channel on intracellular Ca2+ and excitability in a modeled neuron

Proceedings of the National Academy of Sciences of the United States of America
T A Good, R M Murphy

Abstract

beta-Amyloid peptide (A beta), one of the primary protein components of senile plaques found in Alzheimer disease, is believed to be toxic to neurons by a mechanism that may involve loss of intracellular calcium regulation. We have previously shown that A beta blocks the fast-inactivating potassium (A) current. In this work, we show, through the use of a mathematical model, that the A beta-mediated block of the A current could result in increased intracellular calcium levels and increased membrane excitability, both of which have been observed in vitro upon acute exposure to A beta. Simulation results are compared with experimental data from the literature; the simulations quantitatively capture the observed concentration dependence of the neuronal response and the level of increase in intracellular calcium.

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Citations

Apr 25, 2012·Molecular Neurobiology·Michael W Nestor, Dax A Hoffman
May 9, 2008·Neuroreport·Talitha L KerriganHugh A Pearson
Mar 5, 2013·Journal of Theoretical Biology·Natasha P WilsonMariajosé Castellanos
Jun 13, 2006·Neuroscience Letters·Sung Hwan YunBarbara L Trommer
Dec 14, 2007·Molecular BioSystems·Rukhsana Sultana, D Allan Butterfield
May 31, 2018·Molecular Medicine Reports·Mubashir HassanAhmed A Moustafa
Nov 7, 2006·Journal of Neuroscience Methods·Dhara Patel, Theresa Good
Aug 20, 2021·Aging Cell·Eduardo J Fernandez-PerezLuis G Aguayo
Feb 2, 2008·Brain Research·Adrien W SchmidCaroline E Herron

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