PMID: 45285Jan 1, 1979

Effect of beta-blocking agents in hyperthyroidism

Acta Medica Academiae Scientiarum Hungaricae
J FöldesG Gyertyánfy

Abstract

Propranolol modifies peripheral thyroxine metabolism, in opposition to the beta blocking agent GYKI 41099 which has no such effect. Both beta-receptor blockers produce a significant fall in the serum cAMP level of hyperthyroid subjects. It is suggested that the beneficial effect of the beta-blocking agents in hyperthyroidism is partly due to their depressive effect on cAMP production. As far as the action of propranolol is concerned, it may well involve an additional effect on T4 metabolism.

Related Concepts

Novothyral
Tobanum, hydrochloride, (+)-isomer
Propanolamines
Cyclic AMP, (R)-Isomer
CXCL11
Rexigen
Hyperthyroidism
Pulse Rate
Cytomel
Adrenergic beta-Antagonists

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