Effect of beta-endorphin on calcium uptake in the brain

Science
F Guerrero-MuñozC H Li

Abstract

The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.

Citations

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Related Concepts

Metazoa
Calcium
Dose-Response Relationship, Drug
Drug Tolerance
Endorphins
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Synaptosomes
Neurosteroids
Mouse, Swiss
Rats, Laboratory

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