Effect of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor atorvastatin on contractility of the isolated rat heart under normal conditions and during oxidative stress

Bulletin of Experimental Biology and Medicine
V L LakomkinA I Kaminnyi

Abstract

Long-term administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor atorvastatin to rats was accompanied by an increase in the relative weight of the heart and decrease in the rate of pressure development in the isovolumic heart. During oxidative stress induced by addition of 100 microM H2O2 to the perfusate, the decrease in contractile function was more pronounced that in the control. Our results indicate that administration of atorvastatin is accompanied by a decrease in myocardial contractility, which becomes more pronounced under conditions of oxidative stress.

References

Aug 3, 2002·Hypertension·Sandrine DelboscBernard Jover
Jul 9, 2004·Coronary Artery Disease·Hironori Nakagami, James K Liao
Sep 24, 2004·Journal of Molecular and Cellular Cardiology·Min-Sheng ChenJian-Dong Luo
Nov 16, 2004·Trends in Cardiovascular Medicine·Bernd Moosmann, Christian Behl

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Citations

Sep 7, 2016·Bulletin of Experimental Biology and Medicine·Z I Mikashinovich, E S Belousova
Aug 2, 2018·Canadian Journal of Physiology and Pharmacology·Tamara R Nikolic TurnicVladimir I Zivkovic

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