PMID: 11318813Apr 25, 2001Paper

Effect of beta-lactam antibiotics on the in vitro development of resistance in Pseudomonas aeruginosa

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
H Carsenti-EtesseP Dellamonica

Abstract

To investigate whether stepwise selection of resistance mutations may mirror the continued bacterial exposure to antibiotics that occurs in the clinical setting. We examined the in vitro development of resistance to a number of commonly used antibiotics (cefepime, cefpirome, ceftazidime, cefotaxime, piperacillin and imipenem) in Pseudomonas aeruginosa, a significant nosocomial pathogen. Stepwise resistance was assessed by serial passage of colonies located nearest to the inhibition zone on antibiotic-containing gradient plates. The lowest frequencies of spontaneous resistance mutations were found with cefepime and imipenem; these drugs also resulted in the slowest appearance of resistance of spontaneous resistance mutations. In five wild-type P. aeruginosa strains, cefepime-selected isolates required a mean of 30 passages to reach resistance; resistance occurred more rapidly in strains selected with other cephalosporins. P. aeruginosa strains that produced beta-lactamase or non-enzymatic resistance generally developed resistance more rapidly than wild-type strains. For most strains, resistance to all antibiotics except imipenem correlated with increased levels of beta-lactamase activity. Cross-resistance of cephalosporin-select...Continue Reading

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Citations

Dec 5, 2008·Expert Review of Anti-infective Therapy·Andrea EndimianiRobert A Bonomo
Mar 21, 2002·Expert Opinion on Therapeutic Targets·David W Green
Jul 11, 2008·Expert Opinion on Drug Safety·Lorenzo Drago, Elena De Vecchi
Jul 15, 2009·International Journal of Antimicrobial Agents·Mark H Wilcox
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Therese M Chapman, Caroline M Perry

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