PMID: 6104994May 1, 1980Paper

Effect of beta-phenylethylamine on synaptosomal and glial transport of labeled neuromediators

Biulleten' eksperimental'noĭ biologii i meditsiny
A D ZharikovaT A Bakhanshvili

Abstract

The effect of beta-phenylethylamine (beta-PEA) on the accumulation of 14C-serotonin, 14C-glutamate and 3H-gamma-aminobutyric acid (3H-GABA) by synaptosomes of the caudate nucleus and cerebral cortex of rats and rabbits was studied for the first time. beta-PEA inhibits 14C-serotonin influx and exerts no material effect on 14C-glutamate and 3H-GABA uptake. beta-PEA inhibits the synaptosomal and glinal accumulation approximately to the same extent. The data obtained are in good agreement with the concepts of the regulatory role of beta-PEA in the transport of biogenic monoamines in the nerve ending membranes. A similarity of the inhibitory effects of beta-PEA to those of amphetamine is suggested.

References

May 1, 1976·The Journal of Pharmacy and Pharmacology·G B BakerR del Carmine
Jul 1, 1973·Canadian Journal of Biochemistry·D A DurdenA A Boulton
Jan 1, 1972·Biulleten' eksperimental'noĭ biologii i meditsiny·V V ShevtsovR N Glebov

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