PMID: 6160942Dec 1, 1980Paper

Effect of beta-receptor-blocking agents on cardiovascular structural changes in spontaneous and noradrenaline-induced hypertension in rats

Clinical Science
Y YamoriA Ooshima

Abstract

1. Continuous intravenous noradrenaline infusion for 1 week into rats by osmotic minipumps significantly increased blood pressure and left ventricular weight. 2. Concomitant alpha-receptor-blockade infusion significantly lowered blood pressure and the aortic weight without significant reduction in left ventricular weight. 3. Two beta-receptor-blocking agents in noradrenaline-infused rats normalized left ventricular weight and significantly reduced the aortic weight, although blood pressure was still higher than control non-infused rats. 4. In 7-week-old spontaneously hypertensive rats, propranolol (perorally for 2 weeks) did not lower blood pressure but reduced significantly cardiovascular protein synthesis ([14C]lysine and [3H]uridine incorporation into non-collagen protein and RNA respectively) in both left ventricle and aorta. This effect was in contrast to hydralazine, which normalized blood pressure but did not reduce cardiovascular protein synthesis. 5. Results suggest that beta-receptors play a modulating role in the structural cardiovascular response to blood pressure.

Citations

Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J Weissinger
Jul 6, 2001·Journal of Human Hypertension·T TinucciD Mion
Mar 1, 1990·Clinical Cardiology·M LehmannA Schmid
Apr 1, 1989·Circulation·J E BrushD S Goldstein
Jan 1, 1984·European Journal of Clinical Pharmacology·L A FerraraG Vallone
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·J WikstrandM Condorelli
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·T Nakada, Y Yamori
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F León-VelardeJ P Richalet
Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·J D Spence
Jan 1, 1992·Clinical Cardiology·D Georgiou, B H Brundage
Jan 1, 1982·British Journal of Clinical Pharmacology·L J Beilin
Mar 1, 1994·Clinical and Experimental Hypertension : CHE·P GrammasJ Wiener
Jan 1, 1996·Vascular Medicine·A F Lee, A D Struthers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.