Effect of betametasone administration on platelet count in thrombocytopenic and normal pregnant women

Archives of Gynecology and Obstetrics
Stefano Raffaele GiannubiloAndrea Luigi Tranquilli

Abstract

To evaluate the effect of a course of corticosteroids on platelet count in both thrombocytopenic and normal pregnant women. We retrospectively considered 107 pregnant women at 24-34 weeks gestation, who had received betametasone treatment (12 mg i.m. for two consecutive days) for fetal lung maturation. Platelet count was assayed 3 days before and 3-7 days after the treatment. Patients were divided into three classes according to the severity of thrombocytopenia. The mean platelet count significantly increased in all classes of patients to an extent that was inversely related to baseline values. The prevalence of non-responders was 56.7% in normal, and 15.0% in thrombocytopenic pregnant women. Corticosteroids may have a role in the treatment of thrombocytopenia in pregnancy.

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Citations

Apr 22, 2005·Journal of Perinatal Medicine·Juan J PiazzeMaurizio M Anceschi

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