PMID: 3873877May 1, 1985Paper

Effect of betamethasone on the dual reaction to anti-human IgE in man: influence of time interval between administration of drug and anti-IgE

Allergy
R Grönneberg, K Strandberg

Abstract

The influence of the time interval between administration of a glucocorticoid, betamethasone, and anti-IgE on the effect of the drug on the early and late phase response (LPR) to anti-IgE was examined in 38 volunteers in a randomized controlled study. The immediate flare and wheal responses to intradermally (i.d.) injected anti-IgE were inhibited by approximately 20 and 30% respectively by a 10 day i.d. pretreatment period with repeated 50 micrograms doses (total 300 micrograms) of betamethasone (P less than 0.01), whereas responses to histamine were not influenced. A single i.d. injection of 50 micrograms betamethasone 24 h prior to anti-IgE challenge attenuated the wheal response (P less than 0.05), whereas injection of the drug 2 h prior to and together with anti-IgE had no influence on the early response. Corresponding LPRs were reduced approximately 30% throughout the observation period of 1-24 h (P less than 0.01). Injecting the drug i.d. 30 min following anti-IgE challenge had no significant influence on the total observation period (1-24 h) of the LPR but antagonized the LPR by 35% at 6-24 h (P less than 0.01). It is concluded that glucocorticoids inhibit IgE-dependent LPRs. When extending the topical pretreatment perio...Continue Reading

References

Feb 1, 1977·The Journal of Allergy and Clinical Immunology·E H DunskyB Zweiman
Apr 1, 1975·The Journal of Allergy and Clinical Immunology·R I Slott, B Zeweiman
Feb 1, 1976·The Journal of Allergy and Clinical Immunology·J PoothullilR P Day
Jan 1, 1985·Allergy·R Grönneberg, O Zetterström
Jan 1, 1973·The Journal of Allergy and Clinical Immunology·S P GalantH I Maibach
Oct 1, 1974·The Journal of Allergy and Clinical Immunology·R I Slott, B Zweiman
Oct 1, 1982·The Journal of Allergy and Clinical Immunology·W DorschR Geiger
May 1, 1983·The Journal of Allergy and Clinical Immunology·S TingR Lavker
Mar 1, 1982·Prostaglandins, Leukotrienes, and Medicine·A J Fairfax

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Citations

Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Grönneberg, O Zetterström
Jun 25, 2014·American Journal of Veterinary Research·Michelle C WoodwardCherie M Pucheu-Haston

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