Effect of bevacizumab added preoperatively to oxaliplatin on liver injury and complications after resection of colorectal liver metastases

Journal of Surgical Oncology
Anne E M van der PoolCornelis Verhoef

Abstract

Chemotherapy (CTx) before resection of colorectal liver metastases (CRLM) may cause hepatic injury and postoperative complications. To ascertain whether adding bevacizumab, a monoclonal antibody against VEGF, to oxaliplatin-based CTx has an influence on liver injury and postoperative complications. Patients with CRLM who received neoadjuvant CTx and underwent resection between 2003 and 2008 were analyzed whether or not they received bevacizumab added to oxaliplatin-based CTx. The total study group existed of 104 patients: 53 patients received oxaliplatin-based CTx and 51 patients received oxaliplatin-based CTx and bevacizumab. The overall complication rate (29%) was not significantly different between the two groups. The bevacizumab group exhibited less moderate sinusoidal dilatation (8% vs. 28%, P = 0.01). No difference in complication rate was found between patients given fewer than six cycles of oxaliplatin-based CTx and those given six or more cycles, or between patients with a short (<5 weeks) interval between the last dose of oxaliplatin and resection and those in which the interval was longer. Bevacizumab added to oxaliplatin-based CTx may protect against moderate sinusoidal dilatation without significantly influencing m...Continue Reading

References

May 11, 2000·Digestive Surgery·C Couinaud
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A de GramontA Bonetti
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S GordonD Adelman
Feb 1, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter J AllenYuman Fong
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe TournigandAimery de Gramont
Jan 24, 2004·Journal of Hepatology·Claudio A RedaelliJean-François Dufour
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
Jun 5, 2004·The Oncologist·Nishan H Fernando, Herbert I Hurwitz
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Aug 25, 2005·Journal of Surgical Oncology·Frank A ScappaticciHerbert Hurwitz
Mar 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brian DonahowerLaura P James
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyEddie K Abdalla
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas AloiaRené Adam
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
May 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Timothy M PawlikMichael A Choti
Apr 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brigit GruenbergerThomas Gruenberger
Oct 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan B KesmodelBarry W Feig
Feb 10, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M KlingerT Gruenberger
Mar 6, 2009·The Lancet Oncology·Yun Shin ChunJean-Nicolas Vauthey
Mar 11, 2009·Diseases of the Colon and Rectum·Cornelis VerhoefJohannes H W de Wilt

❮ Previous
Next ❯

Citations

Feb 23, 2013·World Journal of Gastroenterology : WJG·De-Bang LiYan-Ming Zhou
Dec 3, 2013·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F LordickM Bartels
Mar 29, 2016·The Surgical Clinics of North America·Michael A WhiteGagandeep Singh
Jul 3, 2015·Molecular and Clinical Oncology·Hidehiro TajimaHiroko Ikeda
May 20, 2015·Annals of Surgical Oncology·Jannemarie A M de RidderIris D Nagtegaal
Apr 5, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuji MorineTohru Utsunomiya
Apr 4, 2016·Clinics and Research in Hepatology and Gastroenterology·Dominique-Charles Valla, Dominique Cazals-Hatem
Feb 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chiara MarzanoDominique-Charles Valla
Jan 7, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K ImaiUNKNOWN Kyusyu Study Group of Clinical Cancer (KSCC) ancillary study
Aug 24, 2013·International Journal of Hepatology·Y Maor, S Malnick
May 26, 2017·The British Journal of Surgery·J ZhaoUNKNOWN Chemotherapy-Associated Liver Injury (CALI) consortium
Mar 3, 2019·Journal of Surgical Oncology·Yoshikuni KawaguchiJean-Nicolas Vauthey
Mar 30, 2019·Annals of Gastroenterological Surgery·Shintaro Yamazaki, Tadatoshi Takayama

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