Effect of Bifidobacterium breve M-16V supplementation on faecal bifidobacteria in growth restricted very preterm infants - analysis from a randomised trial

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Sanjay PatolePatricia Conway

Abstract

Gut development, function and colonisation are impaired in animal models of prematurity with intrauterine growth restriction (IUGR). The effect of Bifidobacterium breve (B. breve) supplementation on faecal bifidobacteria in small for gestational age (SGA: birth weight <10th centile due to IUGR) preterm infants is not known. We compared B. breve M-16V supplementation effect on faecal bifidobacteria in preterm (<33 weeks) SGA versus non-SGA infants in the two arms of our randomised controlled trial. There were no baseline differences in the proportion of detectable B. breve counts between SGA versus non-SGA infants [probiotic: 7 (33%) versus 22 (42%), p = 0.603; placebo: 1 (6%) versus 1 (2%), p = 0.429]. B. breve counts did not differ between SGA and non-SGA infants in response to treatment (p = 0.589), after adjusting for baseline count (p < 0.001) and treatment allocation (p < 0.001). An interaction term between growth status and treatment showed negligible change (p = 0.938). Probiotic treated SGA infants reached full feeds earlier than SGA controls (HR 2.00, 95% CI 1.05-3.82, p = 0.035): Median (IQR): 16 (12-26) versus 19 (11-25) days, after adjustment for age at starting feeds and gestation <28 weeks. Response to B. breve M-...Continue Reading

References

Feb 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·R A CeleskM Wagner
Oct 1, 1978·The American Journal of Clinical Nutrition·D C Savage
May 1, 1989·Journal of Pediatric Gastroenterology and Nutrition·C G AvilaP M Robinson
May 7, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R BauerU Zwiener
May 8, 1999·The American Journal of Clinical Nutrition·R I MackieH R Gaskins
Oct 27, 1999·Journal of Gastroenterology and Hepatology·J M MariadasonP R Gibson
Feb 7, 2001·The American Journal of Clinical Nutrition·A Bezkorovainy
Aug 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·E GaudierC Hoebler
Mar 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alison MostynLynne Clarke
Aug 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·J DorlingA Leaf
Nov 28, 2006·Indian Journal of Pediatrics·Aryeh Simmonds, Edmund F LaGamma
Apr 9, 2008·World Journal of Gastroenterology : WJG·Riina-A KekkonenRiitta Korpela
Oct 1, 2010·Neonatology·Romain D'IncaIsabelle Le Huërou-Luron
Apr 12, 2012·Pediatrics·Alison LeafUNKNOWN Abnormal Doppler Enteral Prescription Trial Collaborative Group
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Aug 27, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Stephen KempleyUNKNOWN ADEPT Trial Collaborative Group
Nov 21, 2014·The American Journal of Clinical Nutrition·Gayatri Athalye-JapeSanjay Patole
Jan 1, 2014·Journal of Oral Biology and Craniofacial Research·Jatin P Shah
Jul 29, 2015·Journal of Pediatric Surgery·Christine S M Lau, Ronald S Chamberlain

❮ Previous
Next ❯

Citations

Feb 1, 2018·Journal of Pediatric Gastroenterology and Nutrition·Chris H P van den AkkerUNKNOWN ESPGHAN Working Group for Probiotics, Prebiotics & Committee on Nutrition
Dec 8, 2017·The Biochemical Journal·Francesca BottaciniMarco Ventura
May 24, 2017·Frontiers in Nutrition·Nicholas D EmbletonStephen P Cummings
Jul 28, 2019·Nutrients·Chyn Boon WongJin-Zhong Xiao
Nov 6, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gayatri Athalye-JapeSanjay Patole

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.