PMID: 11337877May 8, 2001Paper

Effect of bile salts, lipid, and humic acids on absorption of benzo[a]pyrene by isolated channel catfish (Ictalurus punctatus) intestine segments

Environmental Toxicology and Chemistry
L P Weber, R P Lanno

Abstract

Dietary absorption of lipophilic contaminants may be a significant route of exposure in aquatic organisms. Bile salts, lipids, and humic acids are important factors that may influence the intestinal absorption of a contaminant such as benzo[a]pyrene (BaP). We hypothesized that bile salts, monoglycerides, and free fatty acids would increase BaP intestinal absorption, while triglycerides, humic acids, and sediment would decrease BaP intestinal absorption. We have established and validated an in vitro model to examine modification of 3H-BaP absorption in everted intestinal segments from channel catfish (Ictalurus punctatus). Uptake of BaP into the everted intestinal segments continued to increase over the times examined in this study (60 min) and apparently occurs passively; thus, fugacity-based models of uptake are supported. Absorption of BaP into intestinal cells was significantly decreased by the addition of monoglycerides and free fatty acids to bile salts in the incubation media. Addition of triglycerides decreased BaP absorption even further. Humic acids may have decreased BaP intestinal absorption, while natural sediment may have increased BaP absorption. The results of this study suggest that all lipids may decrease intes...Continue Reading

References

Aug 20, 1975·Biochimica Et Biophysica Acta·M I El-GorabJ D Loerch
Mar 1, 1989·Canadian Journal of Physiology and Pharmacology·A B ThomsonM T Clandinin
Sep 1, 1986·Canadian Journal of Physiology and Pharmacology·A RahmanA Rahimtula
Oct 17, 1998·Toxicology and Applied Pharmacology·M SchlummerM S McLachlan

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Citations

Aug 1, 2013·Expert Opinion on Drug Metabolism & Toxicology·Kelly L HarrisAramandla Ramesh
Feb 22, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Stefan de GelderPeter H M Klaren

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