Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis

Arthritis Care & Research
Grant S SchulertAlexei A Grom

Abstract

To assess performance of the 2016 macrophage activation syndrome (MAS) classification criteria for patients with systemic juvenile idiopathic arthritis (JIA) who develop MAS while treated with biologic medications. A systematic literature review was performed to identify patients with MAS while being treated with interleukin (IL)-1 and IL-6 blocking agents. Clinical and laboratory information was compared to a large previously compiled historical cohort. Eighteen publications were identified, and after removing duplicates, 35 patients treated with canakinumab and 49 patients with tocilizumab were available for analysis; 5 anakinra-treated patients were excluded due to limited numbers. MAS classification criteria were less likely to classify tocilizumab-treated patients as having MAS compared to the historical cohort or canakinumab-treated patients (56.7%, 78.5%, and 84%, respectively; P < 0.01). Patients who developed MAS while treated with canakinumab trended towards lower ferritin at MAS onset than the historical cohort (4,050 versus 5,353 ng/ml; P = 0.18) but had no differences in other cardinal clinical or laboratory features. In comparison, patients who developed MAS while treated with tocilizumab were less likely febrile ...Continue Reading

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Citations

Feb 9, 2018·International Immunology·Grant S Schulert, Scott W Canna
Jun 6, 2018·Current Opinion in Rheumatology·Shima Yasin, Grant S Schulert
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Aug 6, 2019·Arthritis & Rheumatology·Grant S SchulertAlexei A Grom
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Jul 19, 2020·Immunologic Research·Carlo PerriconeRoberto Gerli
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Nov 26, 2020·Clinical Reviews in Allergy & Immunology·Chin-An Yang, Bor-Luen Chiang
Jan 2, 2021·Seminars in Arthritis and Rheumatism·Shunli TangHong Fang
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Mar 9, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Michael J Ombrello, Grant S Schulert
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Aug 20, 2019·Annals of the Rheumatic Diseases·Francesca Minoia, Angelo Ravelli
Jun 19, 2021·Expert Review of Clinical Immunology·Silvia RosinaAngelo Ravelli
Jul 3, 2021·International Journal of Molecular Sciences·Giulia Di DonatoFrancesco Chiarelli

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