Effect of Biological Disease-modifying Anti-rheumatic Drugs on Airway and Interstitial Lung Disease in Patients with Rheumatoid Arthritis

Internal Medicine
Izumi KurataTakayuki Sumida

Abstract

Objective Biological disease-modifying anti-rheumatic drugs (bDMARDs) represent an important advance in alleviating rheumatoid arthritis (RA), but their effect on rheumatic airway disease (AD) and interstitial lung disease (ILD) is still unclear. This study was performed to evaluate the association of the use of different bDMARDs with new-onset or worsening of RA-AD/ILD. Methods We performed a retrospective cohort study of RA patients who received bDMARDs and assessed their AD/ILD before and after drug initiation in our hospital over the past 10 years. We evaluated the serial changes in computed tomography (CT), classified patients according to AD/ILD progression, and analyzed associations between clinical characteristics and outcomes. Results We enrolled 49 patients. Thirty patients received tumor necrosis factor inhibitors (TNFis), 12 received abatacept (ABT), and the remaining 7 received tocilizumab (TCZ). Seventeen patients had ILD, 10 had AD, and 6 had both AD and ILD before the initiation of bDMARDs. New emergence or exacerbation of AD/ILD was observed in 18 patients after drug initiation, while the remaining 31 remained stable or improved. Multiple logistic regression analyses revealed that pre-existing AD was an indepen...Continue Reading

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Citations

Apr 16, 2020·Journal of Clinical Medicine·Giulia CassoneMarco Sebastiani
Nov 28, 2019·Drugs & Aging·Riccardo MessinaNicola Scichilone
Oct 18, 2020·Rheumatology·Richard Conway, Elena Nikiphorou
Nov 5, 2020·Expert Opinion on Biological Therapy·Ciro RomanoGiovanna Cuomo
Apr 23, 2021·Autoimmunity Reviews·Esther F Vicente-RabanedaMiguel Á González-Gay
Nov 17, 2020·The Journal of Rheumatology·Vanessa L KronzerJeffrey A Sparks
Mar 30, 2021·Rheumatology·Carlos Fernández-DíazUNKNOWN Spanish Collaborative Group of Interstitial Lung Disease Associated with Rheumatoid Arthritis
May 17, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Jérémie SellamChristophe Richez

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Methods Mentioned

BETA
bronchoalveolar lavage
X-ray

Software Mentioned

SPSS

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