PMID: 3766434Oct 1, 1986Paper

Effect of biotin deficiency and supplementation on lipid metabolism in rats: saturated fatty acids

The American Journal of Clinical Nutrition
S F SuchyB Wolf

Abstract

The effects of biotin deficiency and supplementation upon saturated fatty acids in serum, liver, cerebrum, and cerebellum of rats were investigated. Serum total fatty acids were reduced in deficient animals to 29% of normal. The percentage composition of some odd-chain fatty acids was increased in the serum and liver of deficient rats. The relative composition of most saturated fatty acids with carbon-chain lengths greater than or equal to 22 were increased in serum and liver of deficient rats. In contrast, there were no differences in the brain saturated fatty acids of deficient animals compared to those of normal and supplemented animals. These results may indicate that alterations in saturated fatty acids do not play a major role in the neurologic abnormalities in human biotin or inherited multiple-carboxylase deficiencies.

Citations

Feb 15, 2018·Nutrients·Youichi OgawaTatsuyoshi Kawamura
Sep 2, 2018·Diabetes/metabolism Research and Reviews·Miji KimJesse Roth
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·J Zempleni, D M Mock
Jun 11, 2002·Annual Review of Nutrition·Robert J McMahon
Dec 24, 2018·BioFactors·Ericka Moreno-MéndezCristina Fernández-Mejía
Nov 13, 2004·The Journal of Nutritional Biochemistry·J Zempleni, D M Mock
Nov 16, 2004·The Journal of Nutritional Biochemistry·Anette LandenbergerJanos Zempleni

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