Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia

Neuroscience Letters
Xi-Ji ShuYong-Xun Ai

Abstract

Bis(7)-tacrine (B7T), a novel dimeric acetyl cholinesterase (AChE) inhibitor, has multiple neuroprotective activities against neuronal damage. However, its therapeutic effects in chronic cerebral ischemia remain unknown. In the present study, adult male Sprague-Dawley rats were subjected with permanent ligation of the bilateral common carotid arteries to investigate the roles of B7T on cognitive function, neuronal apoptosis and neurogenesis in the hippocampus. Results from spatial navigation test showed that chronic cerebral ischemia impaired spatial learning, B7T treatment shorten escape latency of ischemia rats as compared with saline-treated rats. Probe trial test indicated that spatial memory deficit of chronic cerebral ischemic animals was reversed by B7T treatment. Immunohistochemical results showed that B7T reduced neuronal apoptosis in the hippocampal CA1 region as compared with ischemia rats, and B7T treatment increased neurogenesis in the hippocampus. These findings suggest that B7T may exert its neuroprotective effects by inhibiting apoptosis and promoting neurogenesis in 2VO rats.

References

Oct 1, 1988·Annals of Neurology·C K ParkJ McCulloch
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T HirataR J Traystman
Jul 29, 1994·Behavioural Brain Research·J C de la Torre, T Fortin
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·F H GageJ Ray
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·V LemaireD N Abrous
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Bernabeu, F R Sharp
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Oct 11, 2003·Molecular and Cellular Neurosciences·Kunlin JinDavid A Greenberg
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elodie DrapeauDjoher Nora Abrous
Jul 28, 2007·Biochemical and Biophysical Research Communications·Jialie LuoYifan Han
Mar 11, 2008·Biochemical and Biophysical Research Communications·Yu-Wei LiuYi-Fan Han
May 27, 2008·Chemico-biological Interactions·Sadaharu KotaniHiroo Ogura

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