Effect of bisphosphonates on periprosthetic bone loss after total knee arthroplasty: a meta-analysis of randomized controlled trials

BMC Musculoskeletal Disorders
Mingmin ShiShigui Yan

Abstract

Aseptic loosening and osteolysis are the most common indications after TKA for revision surgery. This meta-analysis which included high-quality randomized controlled trials (RCTs) aimed to analyze the effect of bisphosphonates (BPs) on maintaining periprosthetic bone mineral density (BMD) after total knee arthroplasty. PubMed, AMED, EMBASE, the Cochrane library, ISI Web of Science, and China National Knowledge Infrastructure were systematically searched, five RCTs were included and the total number of participants was 188. The weighted mean differences with 95% confidence interval were calculated to evaluate the efficacy of BPs on total BMD of knee and the BMD of different periprosthetic regions. A descriptive review was performed for BP-related adverse effects. The BPs group presented significantly higher total BMD in proximal part of the tibia than the control group at 3 and 6 months (P < 0.05), but no significant difference at 12 months (P = 0.09). The BPs group presented significantly higher BMD in the distal aspect of the femur than that in the control group at 3, 6, 12 months. The BPs group presented significantly higher periprosthetic BMD than that in the control group at 3, 6 and 12 months in tibial medial and lateral m...Continue Reading

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Citations

Aug 9, 2019·The Journal of Bone and Joint Surgery. American Volume·Paul A AndersonNeil C Binkley
Apr 27, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Shin MasudaToshifumi Ozaki
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Jul 17, 2021·Archives of Orthopaedic and Trauma Surgery·L ThoreauE Thienpont
Dec 18, 2021·Archives of Orthopaedic and Trauma Surgery·Maximilian M DelsmannChristian Ries

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