Effect of bitter gourd and spent turmeric on constituents of glycosaminoglycans in different tissues in streptozotocin induced diabetic rats

Molecular and Cellular Biochemistry
G Suresh KumarP V Salimath

Abstract

Diet is now one of the well established means in the management of diabetes. Bitter gourd and spent turmeric at 10% level were tested for their efficacy on glycosaminoglycan metabolism in various tissues viz., liver, spleen, lungs, heart and testis in control, diabetic and treated rats. The glycosaminoglycans (GAGs) were isolated from defatted and dried tissues. The contents of sulfated GAGs decreased in all the tissues and the decrease was more prominent in heart and testis. In the isolated GAGs, contents of total sugar, amino sugar, uronic acid and sulfate were studied. Decrease in total sugar content was maximum in testis. Amino sugar content decreased considerably in testis (38%) and lungs (15%). The content of uronic acid also decreased in testis (33%) besides heart (29%) and liver (25%). Sulfate groups in GAGs perform pivotal functions in many biological events and decrease in sulfate content was significant in heart (40%), testis (37%) and liver (37%). GAGs profile on the cellulose acetate electrophoresis revealed that heparan sulfate (HS), hyaluronic acid (HA) and chondroitin sulfate/dermatan sulfate (CS/DS) were present in liver, spleen and lungs. HS, CS were present in heart, DS/CS was observed in testis. The observed...Continue Reading

References

Apr 18, 1975·Biochimica Et Biophysica Acta·S R SrinivasanP Dolan
Oct 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·C H Ts'aoB Schumacher
Apr 1, 1992·Kidney International·J D Scandling, B D Myers
Aug 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·A S Reddi
Mar 1, 1986·Carbohydrate Research·C A Población, Y M Michelacci
Apr 1, 1967·Analytical Biochemistry·J Ludowieg, J D Benmaman
Jul 1, 1972·The American Review of Respiratory Disease·F S WustemanJ C Wagner
Jan 1, 1972·Respiration; International Review of Thoracic Diseases·C D Laros
Jun 1, 1969·Archives of Biochemistry and Biophysics·J F McKelvy, Y C Lee
Nov 28, 1984·Biochimica Et Biophysica Acta·B RadhakrishnamurthyG S Berenson
Jun 6, 1981·British Medical Journal·B A LeatherdaleA H Bignell
Aug 31, 1993·Biochemical and Biophysical Research Communications·C CalabresseD Belpomme
May 29, 2003·The Journal of Nutritional Biochemistry·Chilkunda D NandiniParamahans V Salimath
Apr 15, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mahmoud AshourAbdelkareem El-Bakry
May 20, 2004·Experimental Cell Research·Boris VuillermozYanusz Wegrowski

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Citations

Nov 20, 2015·Food & Function·Kyu-Ho HanMichihiro Fukushima
Jan 1, 2014·Journal of Diabetes and Metabolic Disorders·Gurusiddaiah Suresh Kumar, Paramahans Veerayya Salimath

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