Effect of bivalent human papillomavirus vaccination on pregnancy outcomes: long term observational follow-up in the Costa Rica HPV Vaccine Trial

BMJ : British Medical Journal
Orestis A PanagiotouCosta Rica HPV Vaccine Trial (CVT) Group (see end of manuscript for full list of investigators)

Abstract

To examine the effect of the bivalent human papillomavirus (HPV) vaccine on miscarriage. Observational long term follow-up of a randomized, double blinded trial combined with an independent unvaccinated population based cohort. Single center study in Costa Rica. 7466 women in the trial and 2836 women in the unvaccinated cohort enrolled at the end of the randomized trial and in parallel with the observational trial component. Women in the trial were assigned to receive three doses of bivalent HPV vaccine (n=3727) or the control hepatitis A vaccine (n=3739). Crossover bivalent HPV vaccination occurred in the hepatitis A vaccine arm at the end of the trial. Women in the unvaccinated cohort received (n=2836) no vaccination. Risk of miscarriage, defined by the US Centers for Disease Control and Prevention as fetal loss within 20 weeks of gestation, in pregnancies exposed to bivalent HPV vaccination in less than 90 days and any time from vaccination compared with pregnancies exposed to hepatitis A vaccine and pregnancies in the unvaccinated cohort. Of 3394 pregnancies conceived at any time since bivalent HPV vaccination, 381 pregnancies were conceived less than 90 days from vaccination. Unexposed pregnancies comprised 2507 pregnancie...Continue Reading

Citations

May 14, 2016·Human Vaccines & Immunotherapeutics·Ulla BondeOle Mogensen
Mar 8, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alaa MosbahGhada Barakat
May 10, 2018·The Cochrane Database of Systematic Reviews·Marc ArbynPierre Pl Martin-Hirsch
Mar 8, 2017·Der Onkologe : Organ Der Deutschen Krebsgesellschaft E.V·Nicolas Wentzensen
Oct 20, 2015·Epidemiology·Allen J Wilcox
Mar 30, 2017·The New England Journal of Medicine·Nikolai M SchellerAnders Hviid
Jun 12, 2018·Obstetrics and Gynecology·Elyse O KharbandaJames D Nordin

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BETA
pregnancy test

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