PMID: 6168363Sep 1, 1981Paper

Effect of bleomycin-radiotherapy combination in management of head and neck squamous cell carcinoma

Cancer
P M ShahD D Patel

Abstract

Twenty-five patients with head and neck squamous cell carcinoma were treated with bleomycin-radiotherapy protocol, 15 mg bleomycin I.V. on alternate days followed by radiation within half an hour. The average total dose of bleomycin was 150 mg. Radiotherapy was given daily. Two patients were lost to follow-up very early in the course of the treatment and were removed from the study for statistical purposes. Thirty-six patients with head and neck squamous cell carcinoma who were treated with radiotherapy alone during the same period were used as controls. The patients were followed for two years. The incidence of response rate did not differ significantly between regimens; however the incidence of side effects with bleomycin-radiotherapy, 82.61%, is significantly more than that of radiotherapy alone (52.78%). Median survival time (MST) of those responding to bleomycin-radiotherapy protocol was seven months and 12 days and for radiotherapy responders was six months. Neither the response rate nor the MST improve significantly after pretreatment with bleomycin. On the contrary, the incidence of side effects increased significantly.

References

Feb 1, 1977·Postgraduate Medicine·S DreizenL R Brown
Feb 1, 1977·Cancer·W D Johnston, R M Byers
Aug 1, 1977·The Surgical Clinics of North America·O H Beahrs

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Citations

Jun 1, 1994·Cancer Metastasis Reviews·B A Teicher
Jan 1, 1983·Pharmacology & Therapeutics·P R Twentyman
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J B WeissbergJ J Fischer
Jan 1, 1984·Critical Reviews in Oncology/hematology·M Al-Sarraf

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