PMID: 1592464Jun 1, 1992Paper

Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function

P C WongP B Timmermans


This study examined effects of nonpeptide angiotensin II (Ang II) receptor subtype antagonists on the interaction of sympathetic function and Ang II in pithed rats. Effects of spinal cord stimulation (0.5-4 Hz) and norepinephrine (0.3-3 micrograms/kg i.v.) on mean arterial pressure (recorded with a carotid arterial catheter), cardiac output (measured with an electromagnetic flowmeter and flow probe around the thoracic ascending aorta), total peripheral resistance, and heart rate were determined. The subtype 1-selective Ang II receptor antagonist losartan (previously known as DuP 753) at 10 mg/kg i.v. blocked the hemodynamic responses to Ang II at 1 microgram/kg i.v. It inhibited mean arterial pressure and total peripheral resistance responses but not cardiac output and heart rate responses to spinal cord stimulation. In contrast, it reduced mean arterial pressure and cardiac output responses but not total peripheral resistance and heart rate responses to intravenous norepinephrine. Given at 100 mg/kg i.v., the subtype 2-selective receptor antagonist PD123177 did not reduce hemodynamic responses to intravenous Ang II, spinal cord stimulation, and intravenous norepinephrine. These results suggest that endogenous Ang II facilitate...Continue Reading


Nov 1, 1993·Journal of Clinical Pharmacology·R T EberhardtW H Frishman
Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R L Chevalier, B A Thornhill
Jan 4, 1994·European Journal of Pharmacology·M Cierco, A Israel
Oct 9, 2001·Clinical Therapeutics·K Dickstein
Aug 29, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shin-ichiro MasudaSatoshi Umemura
Jun 20, 2002·Journal of Cardiovascular Pharmacology·Jippe C BaltPieter A van Zwieten
Dec 12, 2003·Journal of Cardiovascular Pharmacology·Alexander NapPieter A van Zwieten
Aug 2, 2008·Journal of Cardiovascular Pharmacology·Tetsumasa SasaokaYasuo Matsumura
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·H YokoyamaH Fujiwara
Jan 5, 2002·Expert Opinion on Investigational Drugs·M WhiteJ de Champlain
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·T A JenkinsF A Mendelsohn
Jan 29, 2011·Clinical and Experimental Hypertension : CHE·Kazuhiro KobayashiHiromichi Suzuki
Apr 7, 1994·The American Journal of Cardiology·J de ChamplainR Nadeau
Jun 5, 2004·Regulatory Peptides·Kenneth M BakerRajesh Kumar
Apr 25, 2006·Autonomic Neuroscience : Basic & Clinical·Anita IsraelMaria del Rosario Garrido
Feb 17, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Y TakataH Kato
Oct 12, 2016·Autonomic Neuroscience : Basic & Clinical·Yimin YaoIvan A Sammut
Jul 17, 2004·Autonomic & Autacoid Pharmacology·A NapP A Van Zwieten
Dec 23, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alexander NapPieter A van Zwieten
Jun 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alexander NapPieter A van Zwieten
Feb 4, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jippe C BaltPieter A van Zwieten
Mar 12, 1998·Hypertension·P F DillonD D Holsworth
May 3, 2002·Journal of Human Hypertension·A Israel, B Sosa-Canache
Aug 27, 2002·Journal of Hypertension·Alexander NapPieter A Van Zwieten
Aug 4, 1998·The American Journal of Physiology·X H JinR M Carey
Apr 25, 2018·Temperature : Multidisciplinary Biomedical Journal·Brett R ElyChristopher T Minson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.