Effect of blood flow occlusion on laser hyperthermia for liver metastases

The Journal of Surgical Research
V MuralidharanChris Christophi

Abstract

Interstitial laser hyperthermia (ILH) is an in situ ablative technique for the treatment of colorectal liver metastases. A significant factor limiting tumor destruction is hepatic blood flow. Modulation of hepatic blood flow may increase the size of tumor necrosis achieved. Our aim was to investigate the effect of blood flow occlusion on ILH-induced necrosis in both tumor and normal liver tissue. A model of colorectal liver metastases in male inbred CBA mice was used. ILH was applied to normal liver and tumor tissue using a bare optical quartz fiber from an SYL500 Nd:YAG surgical laser generator, with and without hepatic blood flow occlusion, and the extent of necrosis was studied. Tumor blood flow was assessed by laser Doppler flowmetry and scanning electron microscopy. Hepatic blood flow occlusion resulted in a significant reduction in blood flow in normal liver tissue (37.9% +/- 5.8, P < 0.001) and in the periphery of the tumor (17.5% +/- 7.8, P < 0.001). It did not affect the blood flow in the center of the tumor (13.4% +/- 4.3, P = 0.07). ILH of normal liver tissue, at low power (2 W), with hepatic blood flow occlusion, resulted in a significant increase in the diameter of necrosis. This effect was not seen when higher pow...Continue Reading

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Citations

Jan 27, 2005·Photomedicine and Laser Surgery
Dec 23, 2011·Radiology Research and Practice·Claudio Maurizio PacellaGiovanni Giuseppe Di Costanzo
Dec 17, 2008·World Journal of Gastroenterology : WJG·Antony Lawrence Gough-Palmer, Wladyslaw Michal Witold Gedroyc
Jul 16, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M NikfarjamC Christophi
Mar 23, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Theodora FifisChristopher Christophi
Feb 18, 2006·ANZ Journal of Surgery·Mehrdad NikfarjamChristopher Christophi
Aug 9, 2005·The Journal of Surgical Research·Mehrdad NikfarjamChristopher Christophi
Feb 25, 2014·Nature Reviews. Cancer·Katrina F Chu, Damian E Dupuy
Aug 29, 2003·The British Journal of Surgery·M Nikfarjam, C Christophi
Jun 15, 2005·Lasers in Surgery and Medicine·Mehrdad NikfarjamChristopher Christophi

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