Abstract
The influence of changes in systemic blood gas and pH values on the thromboembolic reaction following wall puncture was studied in rabbit mesenteric arterioles and venules (diameter 20-40 microns), using intravital video-microscopy. Under normal circumstances the number of emboli produced was higher in arterioles than in venules (6 and 1, respectively). The initial thrombus growth, the number of emboli produced per vessel and the total duration of the embolisation period were not significantly influenced by changes in blood gas and pH values in both arterioles and venules. Therefore, the observed difference in thromboembolic reaction between arterioles and venules cannot be explained by differences in blood gas and pH values in these microvessels. Since reduced velocity, as a measure of wall shear rate, did not correlate with the thromboembolic reaction in arterioles or venules, fluid dynamics can also not explain the difference, indicating that the thrombogenic or antithrombogenic activity of arteriolar and venular walls differs following injury. A combination of hypercapnia and hypoxia was found to result in a prolongation of the average time period needed to produce a new embolus in both vessel types. This prolongation in em...Continue Reading
References
Jan 1, 1977·Thrombosis Research·S S Tang, M M Frojmovic
Jun 1, 1986·Thrombosis Research·J VermylenF De Clerck
Jun 1, 1986·Pflügers Archiv : European journal of physiology·A DeussenJ Schrader
Nov 1, 1986·Circulation Research·G J TangelderR S Reneman
Jul 1, 1972·Chemical & Pharmaceutical Bulletin·K KikugawaM Ichino
May 1, 1973·Microvascular Research·M Intaglietta, W R Tompkins
Nov 15, 1973·Experientia·B Goldschmidt
Mar 1, 1974·British Journal of Haematology·P Han, N G Ardlie
Apr 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A B Rogers, R M Des Prez
Nov 1, 1970·Circulation Research·B R Duling, R M Berne
May 1, 1984·Pflügers Archiv : European journal of physiology·R BusseU Pohl
May 1, 1982·British Journal of Pharmacology·S Moncada
Jul 1, 1981·Microvascular Research·D W SlaafT Arts
Nov 1, 1981·Microvascular Research·P S KennedyR T Solis
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS
Citations
Mar 21, 2003·Vascular Pharmacology·Hanna BillertMaciej Kurpisz
May 30, 1998·Anesthesiology·S Delaporte-CerceauP Coriat
May 13, 1999·Anesthesiology·B Quaknine-OrlandoP Coriat
Jul 13, 2013·The Veterinary Record·K EatwellA Meredith
Jun 1, 1996·Critical Care Medicine·R Germann, P Werner
Sep 16, 2011·Microsurgery·Krzysztof Kusza, Maria Siemionow
Mar 15, 1990·Thrombosis Research·M G oude EgbrinkR S Reneman
Feb 26, 2004·Anesthesia and Analgesia·Emmanuel MarretCharles-Marc Samama
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·M A BroedersM G Egbrink
Feb 1, 1992·Circulation Research·M G oude EgbrinkR S Reneman
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·M A BroedersM G oude Egbrink
Apr 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Martijn A W BroedersMirjam G A oude Egbrink
Nov 1, 1995·Medical & Biological Engineering & Computing·Y BenmakrohaP Rolfe