Effect of blood pressure and glycemic control on the plasma cell-free DNA in hemodialysis patients

Kidney Research and Clinical Practice
Da Wun JeongSang-Ho Lee

Abstract

The plasma levels of cell-free DNA (cfDNA) are known to be elevated under inflammatory or apoptotic conditions. Increased cfDNA levels have been reported in hemodialysis (HD) patients. The aim of this study was to investigate the clinical significance of cfDNA in HD patients. A total of 95 patients on HD were enrolled. We measured their predialysis cfDNA levels using real-time EIF2C1 gene sequence amplification and analyzed its association with certain clinical parameters. The mean plasma cfDNA level in the HD patients was 3,884 ± 407 GE/mL, and the mean plasma cfDNA level in the control group was 1,420 ± 121 GE/mL (P < 0.05). Diabetic patients showed higher plasma cfDNA levels compared with nondiabetic patients (P < 0.01). Patients with cardiovascular complications also showed higher plasma cfDNA levels compared with those without cardiovascular complication (P < 0.05). In univariable analysis, the cfDNA level was associated with 3-month mean systolic blood pressure (SBP), white blood cell, serum albumin, creatinine (Cr), normalized protein catabolic rate in HD patients. In diabetic patients, it was significantly correlated with SBP, hemoglobin A1c, and serum albumin. In multivariate analysis, SBP was the independent determina...Continue Reading

References

Feb 13, 2001·Kidney International. Supplement·B L JaberB J Pereira
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Richard J LevineDiana W Bianchi
Oct 8, 2008·Annals of the New York Academy of Sciences·Marie KorabecnaAles Horinek
Apr 22, 2010·Nucleosides, Nucleotides & Nucleic Acids·Shereen A El TarhounyNashwa M Al Azizi
Dec 7, 2010·European Journal of Clinical Investigation·Johanna AtamaniukKarl M Stuhlmeier
Dec 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nai-Wen TsaiCheng-Hsien Lu
May 13, 2011·Nature Reviews. Cancer·Heidi SchwarzenbachKlaus Pantel
Dec 15, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johanna AtamaniukThomas Weichhart
Jul 27, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David TovbinAmos Douvdevani
Sep 26, 2013·International Journal of Molecular Sciences·Yahya I ElshimaliJaydutt V Vadgama
Jun 7, 2014·Critical Care : the Official Journal of the Critical Care Forum·Jose Garnacho-MonteroAntonio Puppo-Moreno

❮ Previous
Next ❯

Citations

May 23, 2017·Nature Communications·Jelka PoharMojca Benčina
Feb 1, 2018·Journal of Experimental & Clinical Cancer Research : CR·Enrico VizzaLucia Cicchillitti
Jan 5, 2020·International Journal of Legal Medicine·Katrin BrodbeckSteffen Peldschus
Jan 19, 2018·Expert Reviews in Molecular Medicine·Peter CelecPeter Boor
Nov 26, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Marie Korabecna, Vladimir Tesar
Mar 15, 2020·Diagnostics·Jordanka HomolováJanka Bábíčková
Jan 25, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Iuliia A PolinaKristine Y DeLeon-Pennell
Apr 30, 2021·Transplantation Direct·Suphamai BunnapradistErik L Lum
Nov 10, 2021·ELife·Nicole Laurencia YuwonoCaroline Elizabeth Ford

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.