PMID: 2502357Mar 1, 1989Paper

Effect of blood product medium supplements on the activity of cefotaxime and other cephalosporins against Enterococcus faecalis

Diagnostic Microbiology and Infectious Disease
G M EliopoulosR C Moellering

Abstract

The activities of cefotaxime and other aminothiazoyl oxime cephalosporins against Enterococcus faecalis were enhanced by addition of 5% sheep blood to Mueller-Hinton agar. This effect was not seen with aztreonam (aminothiazoyl oxime monobactam), cefotiam (aminothiazoyl, nonoxime), or other cephalosporins, and it was specific to the syn-configuration of the oxime moiety. Enhancement of cefotaxime activity was demonstrable against approximately 50% of 86 clinical isolates and could only be shown at low bacterial inocula. Human serum, serum alpha 1-, beta- and gamma-globulin fractions and albumin often antagonized or did not affect significantly the antimicrobial activity of cefotaxime, while the alpha 2-globulin fraction usually enhanced drug activity. The in vivo activity of cefotaxime against E. faecalis was examined in a rat peritoneal abscess model. The test organism was resistant to cefotaxime by standard methods (MIC greater than 128 micrograms/ml) but was inhibited by 1.0 microgram/ml when rat serum was presented in the medium. Cefotaxime reduced titers of bacteria within abscesses after 5 days of therapy (5.77 +/- 0.68 log10 CFU/g) in comparison with those in control animals (7.38 +/- 0.28 log10 CFU/g, p less than 0.05). ...Continue Reading

References

Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Nov 1, 1982·Reviews of Infectious Diseases·R C Moellering
Sep 1, 1982·Reviews of Infectious Diseases·C R Smith
Dec 1, 1982·European Journal of Clinical Microbiology·L M SwitalskiT Wadström
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·P H ChandrasekarB Carr
May 1, 1984·Mayo Clinic Proceedings·W R WilsonJ E Rosenblatt
Sep 1, 1982·Annals of Internal Medicine·H C Neu
Aug 1, 1982·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering

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Citations

Nov 1, 1991·Diagnostic Microbiology and Infectious Disease·R N JonesD M Johnson
Sep 1, 1991·Diagnostic Microbiology and Infectious Disease·B M BriggsD M Johnson
Jan 1, 1992·Diagnostic Microbiology and Infectious Disease·R N JonesM Bale
Jul 27, 1999·International Journal of Antimicrobial Agents·L AlouJ Prieto
Feb 1, 1994·The Journal of Hospital Infection·J R Kerr
Apr 9, 1990·The American Journal of Medicine·H C Neu
Feb 1, 1994·Journal of Clinical Microbiology·B J BuschelmanM J Bale

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