Effect of blood thiamine concentrations on mortality: Influence of nutritional status

Nutrition
H P LeiteÂngela Tavares Paes

Abstract

To test the hypothesis that low blood thiamine concentrations in malnourished critically ill children are associated with higher risk of 30-d mortality. Prospective cohort study in 202 consecutively admitted children who had whole blood thiamine concentrations assessed on admission and on days 5 and 10 of intensive care unit (ICU) stay. The primary outcome variable was 30-d mortality. Mean blood thiamine concentrations within the first 10 d of ICU stay, age, sex, malnutrition, C-reactive protein concentration, Pediatric Index of Mortality 2 score, and severe sepsis/septic shock were the main potential exposure variables for outcome. Thiamine deficiency was detected in 61 patients within the first 10 d of ICU stay, 57 cases being diagnosed on admission and 4 new cases on the 5th d. C-reactive protein concentration during ICU stay was independently associated with decreased blood thiamine concentrations (P = 0.003). There was a significant statistical interaction between mean blood thiamine concentrations and malnutrition on the risk of 30-d mortality (P = 0.002). In an adjusted analysis, mean blood thiamine concentrations were associated with a decrease in the mortality risk in malnourished patients (odds ratio = 0.85; 95% confi...Continue Reading

Citations

Jan 16, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Bertha F PolegatoMarcos F Minicucci
Jan 1, 2021·Journal of Tropical Pediatrics·Kumar Manish RajArushi Gahlot Saini
Mar 13, 2021·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Zengzheng GeYi Li
Aug 2, 2021·Pediatric Research·Eric L WaldL Nelson Sanchez-Pinto

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