PMID: 20642102Jul 21, 2010Paper

Effect of body iron stores in the indicators of alcohol abuse and alcoholic liver injury

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Bogdan CylwikMaciej Szmitkowski

Abstract

Chronic alcohol abuse disrupts iron homeostasis in the body leading to its deposition in the liver. Accumulation of iron in the liver can lead to organ damage and the development of alcoholic liver disease. To assess the impact of body iron stores, as defined by ferritin and transferrin saturation in alcoholics on the value of the indicators of alcohol abuse (carbohydrate-deficient transferrin and the mean corpuscular volume of red blood cells) and the indices of alcoholic liver damage (gamma-glutamyltransferase, aspartate and alanine aminotransferase). The study group consisted of 148 alcohol-dependent men who were divided into five groups according to the body iron stores (criterion ferritin) and the depletion of these stores (criterion transferrin saturation). Indices of body iron stores (hemoglobin, mean corpuscular volume, serum iron level, concentration and transferrin saturation, serum soluble transferrin receptor, ferritin) and indicators of alcohol abuse (GGT, AST, ALT and CDT) were determined. Only the indices of alcoholic liver damage (GGT, AST and ALT) were different between the alcoholics with a positive and compensated iron balance evaluated by serum ferritin level. Indicators of alcohol abuse--CDT and MCV--were n...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Kyle J ThompsonLaura W Schrum
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Carmen Garcia-Ruiz, José C Fernandez-Checa
Alcoholism, Clinical and Experimental Research
Deanna L HowarthKirsten C Sadler
© 2021 Meta ULC. All rights reserved