Effect of Body Mass Index on Survival in Breast Cancer Patients According to Subtype, Metabolic Syndrome, and Treatment

Clinical Breast Cancer
Won Kyung ChoSoohyun Ahn

Abstract

To investigate the effect of body mass index (BMI) on survival in patients with breast cancer according to tumor subtype, metabolic syndrome, and systemic treatment. We identified 5668 patients who underwent curative surgery for breast cancer between 1996 and 2013 from the clinical data of a single institution. Disease-free survival (DFS) and overall survival (OS) were calculated and compared between the patients with BMI ≥ 25 kg/m2 and < 25 kg/m2 in all patients and in specific subgroups, including tumor subtype, metabolic syndrome, and systemic treatment. In all patients, BMI ≥ 25 kg/m2 was an unfavorable factor for OS (P = .030) but not for DFS. In the HR+/HER2- subgroup, DFS and OS were longer in patients with BMI < 25 kg/m2 than ≥ 25 kg/m2 (P = .012 and .005, respectively). In patients with more than one metabolic syndrome, BMI was an unfavorable factor for OS (hazard ratio, 2.669; P < .001) CONCLUSION: BMI ≥ 25 kg/m2 was an unfavorable survival factor, particularly in patients with HR+/HER2- breast cancer.

Citations

Sep 2, 2020·Cancers·Diego A PedrozaRajkumar Lakshmanaswamy
Sep 17, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Sofia LaforestCaroline Diorio
Dec 31, 2020·International Journal of Endocrinology·Elías Cardoso-PeñaJosé de Jesús Garduño García
Apr 13, 2021·Frontiers in Oncology·Shuwen DongXiaosong Chen
Feb 24, 2021·Journal of the National Cancer Institute·Ana Elisa LohmannPamela J Goodwin
Sep 30, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jennifer Y ShengAntonio C Wolff

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