Effect of Body Weight on Metabolic Hormones and Fatty Acid Metabolism in Follicular Fluid of Women Undergoing In Vitro Fertilization: A Pilot Study

Reproductive Sciences
Laurice Bou NemerOrhan Bukulmez

Abstract

Obesity is an epidemic affecting more than one-third of adults in the United States. Obese women experience decreased fertility, explained in part by oocyte quality. Since follicular fluid (FF) provides an important microenvironment for oocyte growth, we sought to evaluate the effect of increased body weight on FF levels of 11 metabolic hormones and fatty acid metabolism. The FF was collected from 25 women (10 normal weight, 10 overweight, and 5 obese) with diminished ovarian reserve undergoing in vitro fertilization (IVF) following a minimal stimulation protocol. Hormone levels were determined by multiplex immunoassay using the MAGPIX (Luminex, Austin, Texas) instrument. Fatty acid metabolites were determined using gas and ultra-high pressure liquid chromatography coupled with mass spectrometry. Levels of hormones related to glucose and energy homeostasis and regulation of fat stores (insulin, glucagon, glucagon-like peptide-1, C-peptide, and leptin) were increased significantly in FF from obese women compared to FF from nonobese(normal weight and overweight) women. Interestingly, FF levels of branched-chain amino acids (BCAA) isoleucine, leucine, and valine as well as uric acid, isocaproic acid, butanoic acid, tyrosine, threo...Continue Reading

References

Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Georgios AnifandisNikolaos Vamvakopoulos
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Jan 17, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Reinhard Stöger
May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Jun 18, 2010·Fertility and Sterility·Yan-Wen XuCan-Quan Zhou
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition
Aug 9, 2011·Fertility and Sterility·Barbara LukeUNKNOWN Society for Assisted Reproductive Technology writing group
Oct 18, 2012·Seminars in Reproductive Medicine·Banu KumbakOrhan Bukulmez
Oct 2, 2013·Human Reproduction Update·Catherine E Aiken, Susan E Ozanne
Oct 6, 2015·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Dec 4, 2015·Biology of Reproduction·Dawn R Sessions-BresnahanElaine M Carnevale
Dec 15, 2015·Human Reproduction Update·A CatteauT Fréour
May 29, 2016·The Biochemical Journal·Joëlle Dupont, Rex J Scaramuzzi
Sep 16, 2016·Reproductive Sciences·Laurice Bou NemerSteven J Ory
Jan 28, 2017·Journal of Animal Science and Biotechnology·Shihai ZhangShiyan Qiao

❮ Previous
Next ❯

Citations

Jan 3, 2019·American Journal of Physiology. Endocrinology and Metabolism·Meghan L RuebelAline Andres
May 24, 2020·International Journal of Molecular Sciences·Katarzyna ZorenaMałgorzata Mrugacz
Nov 24, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiaojiao ChenXiufeng Ling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Related Papers

Reproduction, Fertility, and Development
Tawiwan PantasriRebecca L Robker
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Tawiwan Pantasri, Robert John Norman
© 2022 Meta ULC. All rights reserved