Effect of bone morphogenic protein-7 on the expression of epithelial-mesenchymal transition markers in silicosis model

Experimental and Molecular Pathology
Yan WangLin Tian

Abstract

This study presented the effect of bone morphogenic protein-7 (BMP-7) inhibiting epithelial-mesenchymal transition (EMT) in silicosis model. In vivo, Wistar rats were exposed to silica by intratracheal instillation. Seven days later rats were treated with BMP-7. Rats were sacrificed at 15 and 30days after exposure of silica. The results demonstrated vimentin expression was down-regulated; and E-cadherin was up-regulated after intervention with BMP-7. The TGF-β expression and phosphorylation-p38 were lower in BMP-7 treated group than in silica group. In vitro, p38 MAPK/Snail signaling pathway was involved in the occurrence of EMT in A549 cells treated by silica. EMT was inhibited by BMP-7. The data showed BMP-7 inhibited EMT induced by silica associated with inhibition of p38 MAPK/Snail pathway.

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Citations

Oct 25, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jingjin YangChunhui Ni
Jul 28, 2019·Current Medical Science·Bo-Nan ZhangFang Yang
Feb 29, 2020·Molecular and Cellular Biochemistry·Neslihan AksuSuna Sabuncuoğlu
Apr 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Juan WuDa-Yi Chen

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