Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation.

British Journal of Pharmacology
Francesca BorrelliAngelo A Izzo

Abstract

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride. The inhibitory effect of BSE on acetylcholine-induced contractions was reduced by the L-type Ca(2+) channel blockers verapamil and nifedipine, but not by the sarcoplasmic reticulum Ca(2+)-ATPase inhibitor cyclopiazonic acid, by the phosphodiesterase type IV inhibitor rolipram or by the lipoxygenase inhibitor zileuton. 3-acetyl-11-keto-beta-boswellic acid, one of the main active ingredients of B. serrata, inhibited acetylcholine-induced contractions. BSE inhibited upper gastrointestinal transit in croton oil-treated mice as well as castor oil-induced diarrhoea. However, BSE did not affect intestinal motility in control mice, both in the small and in the large intestine. It is concluded that BSE directly inhibits intestinal motili...Continue Reading

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Citations

Mar 4, 2014·Journal of Ethnopharmacology·Malik Hassan MehmoodAnwarul-Hassan Gilani
Sep 30, 2008·Pakistan Journal of Biological Sciences : PJBS·Mohammad Kazem Gharib NaseriMarzie Omidi Birgani
Apr 21, 2009·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Witness D H Chiwororo, John A O Ojewole
Mar 29, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sadiq UmarHaider A Khan
Jan 26, 2016·International Journal of Molecular Sciences·Fernando Pereira BeserraClélia Akiko Hiruma-Lima
Apr 21, 2009·Natural Product Reports·Bhahwal Ali ShahSubhash Chandra Taneja
Jan 4, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Raffaele CapassoAngelo A Izzo
Mar 13, 2014·Phytotherapy Research : PTR·Renata Minuzzo HartmannNorma Possa Marroni
Nov 18, 2010·Digestive Diseases and Sciences·Malik Hassan MehmoodAnwarul-Hassan Gilani
Jun 22, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F BorrelliA A Izzo
Jul 16, 2020·Advanced Pharmaceutical Bulletin·Asiyeh JebelliMohammad Rahmati-Yamchi
Aug 28, 2007·Pharmazie in unserer Zeit·Sara L CrockettRudolf Bauer
Dec 14, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F BorrelliA A Izzo
Apr 24, 2009·Archives of Pharmacal Research·Ike Campomayor Dela PeñaJae Hoon Cheong
Mar 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Filipe R M B OliveiraFabiana A Cavalcante
Apr 27, 2021·Biochemistry and Biophysics Reports·Nazim Uddin EmonMohammad Mehedi Hasan Tanvir

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