PMID: 9167750Jun 1, 1997Paper

Effect of brain irradiation on blood-CSF barrier permeability of chemotherapeutic agents

American Journal of Clinical Oncology
D X QinZ Tang

Abstract

Effect of irradiation on blood-cerebrospinal fluid (CSF) barrier (BCB) was studied quantitatively by observing the effect of methotrexate (MTX) permeation into the CSF before, during, and after brain irradiation after i.v. injection of MTX. Observation of 15 brain tumor patients indicated that in large brain tumors, the BCB was seriously damaged; in small tumors, the BCB would gradually open. Compared with the findings before irradiation, the increase of permeability of MTX was zero to threefold. It is thus advisable to give chemotherapy only after 20 Gy of irradiation.

References

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Citations

Dec 17, 2010·Cancer Chemotherapy and Pharmacology·Amit KhatriMark N Kirstein
Mar 21, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ewa BienAnna Balcerska
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·D QinX Gu
Aug 26, 1998·American Journal of Clinical Oncology·M L GruberA Nirenberg
Jul 7, 2007·Neurosurgical Focus·Martin A BaggenstosRussell R Lonser
Dec 2, 2008·Seizure : the Journal of the British Epilepsy Association·Rebecca E Fasano, Donna C Bergen
Jun 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jonathan KhalifaUNKNOWN International Association for the Study of Lung Cancer Advanced Radiation Technology Committee
Jun 1, 2006·Expert Review of Neurotherapeutics·Myke R GreenMarc Chamberlain
Aug 28, 2019·Genes·Anna MichaelidesováMartina Zíková
Oct 13, 2020·American Journal of Clinical Oncology·Mark A D'Andrea, G Kesava Reddy
Nov 7, 2019·American Journal of Clinical Oncology·Mark A D'Andrea, G Kesava Reddy

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