PMID: 2118408Aug 1, 1990Paper

Effect of branched chain amino acid enrichment of total parenteral nutrition on nitrogen sparing and clinical outcome of sepsis and trauma: a prospective randomized double blind trial

The British Journal of Surgery
M F von MeyenfeldtD J Gouma

Abstract

Administration of extra branched chain amino acids (BCAA) has been associated with a nitrogen sparing effect in septic and traumatized patients. Whether nitrogen sparing is associated with decreased morbidity and mortality rates is unknown. We therefore undertook a prospective, randomized, double blind trial investigating the effects of BCAA enrichment of a total parenteral nutrition (TPN) regimen on nitrogen balance, 3-methylhistidine excretion, morbidity as evidenced by disturbances in organ function, severity of sepsis and mortality. One hundred and one patients entered the study; 52 received a standard TPN solution and 49 a BCAA-enriched solution. Both groups received 30 kcal kg-1 body-weight, 15 per cent fat calories and 0.17 g nitrogen kg-1 body-weight. In the BCAA-enriched group, patients received 0.56 g BCAA kg-1 body-weight (50.2 per cent BCAA). Standard group patients received 0.18 g BCAA kg-1 body-weight (15.6 per cent BCAA). Nitrogen balances and 3-methylhistidine excretion were not significantly different between groups. Although morbidity scores tended to decrease during the study no difference was observed between groups. Mortality (early or late), sepsis or stress-related, did not differ significantly between gr...Continue Reading

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Citations

Sep 27, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L Cynober
Jan 1, 1992·Nutrition Research Reviews·K LundholmR Sandström
Mar 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·A J Wagenmakers
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Jul 28, 2010·Indian Journal of Anaesthesia·Koneru Veera Raghava Chowdary, Pothula Narasimha Reddy
Oct 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·O PitkänenA Kari
Feb 26, 2004·Critical Care Clinics·D Sue Slone
Jul 18, 2000·The Surgical Clinics of North America·G P Dabrowski, J L Rombeau
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Feb 21, 2009·International Journal of Occupational Medicine and Environmental Health·Willibrord BeemsterboerFrans Nijhuis
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Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Stuart M PhillipsPeter J M Weijs
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Dec 21, 2005·The Journal of Nutrition·Phillip C Calder
Aug 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S KleinP Twomey

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