Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion

Neuroreport
Hiroyuki IchikawaTomosada Sugimoto

Abstract

Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.

References

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Citations

May 6, 2004·Brain Research. Developmental Brain Research·H IchikawaT Sugimoto
Oct 1, 2020·Journal of Neurophysiology·Rebecca Nicole LeesTudor Constantin Badea

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