Effect of bromocriptine on plasma catecholamines in normal subjects and prolactin-secreting tumor patients

Journal of Endocrinological Investigation
A M ManciniI Molocznik

Abstract

The effect of short term bromocriptine (5 mg/day, 5 days) on plasma epinephrine (E), norepinephrine (NE), dopamine (DA) and prolactin (PRL) was studied in 4 normal women and 6 bearing PRL-secreting tumors. When studied on placebo no significant differences were found between controls and patients in E, NE and DA plasma levels. Bromocriptine induced: a 70% decrease in PRL levels in both groups, a significant (p less than 0.05) decrease in plasma NE levels in the control group, no significant change in plasma NE levels in the hyperprolactinemic patients when considered as a group. These results do not indicate that bromocriptine is a useful tool in the diagnosis of defective central dopaminergic regulation since individual responses of the PRL-secreting tumor patients were variable. Nevertheless, the impaired response of the group as a whole may be suggesting an underlying alteration of DA2 receptor activity in these tumor patients.

References

Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·P N PrinzM Raskind
May 1, 1979·The Journal of Clinical Endocrinology and Metabolism·G R Van Loon
Apr 1, 1978·European Journal of Clinical Investigation·T Akerstedt, L Levi
Jan 1, 1979·Neuroendocrinology·G R Van LoonJ L Ruse
Feb 1, 1979·Clinical Pharmacology and Therapeutics·M G ZieglerO Steinsland
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·Y N SinhaW P VanderLaan
Jan 1, 1984·Annals of Internal Medicine·M L VanceM O Thorner
Oct 1, 1980·The Journal of Clinical Endocrinology and Metabolism·L WhitfieldM S Golub
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·D E BybeeI J Kopin
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M MannelliM Serio
Mar 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R M CareyD L Kaiser
May 1, 1983·Journal of the Autonomic Nervous System·I ArmandoM Barontini

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Citations

Jun 1, 1995·Journal of Autonomic Pharmacology·S NowickiM M Elias

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