PMID: 7024721Oct 1, 1981Paper

Effect of buformin on splanchnic carbohydrate and substrate metabolism in healthy man

Metabolism: Clinical and Experimental
P Bratusch-MarrainP Nowotny

Abstract

The effect of buformin (100 mg b.i.d. for 5 days) on carbohydrate metabolism, both splanchnic glucose output (SGO) and net substrate exchange were studied in 6 healthy male volunteers in the basal state and following glucose ingestion (100 g). Control studies without buformin were also performed in 5 men. Splanchnic glucose and substrate exchange was determined by means of the hepatic venous catheter technique. SGO was 154 +/- 18 (SEM) mg/min in the postabsorptive state and increased 33.3 +/- 2.8 g above the basal level during the 150 min period following glucose ingestion. Buformin administration did not alter basal SGO (157 +/- 26 mg/min), nor the splanchnic exchange of pyruvate, alanine, glycerol, OH-butyrate and acetoacetate. Splanchnic lactate balance was altered by buformin and net lactate output occurred. Following glucose ingestion the rise in splanchnic lactate output was increased, whereas no change in SGO (32.9 +/- 3.5 g/150 min) and splanchnic exchange of the other substrates was observed. The increase in arterial blood glucose concentration following oral glucose loading was reduced by buformin pretreatment (p less than 0.005). The insulin production rate (basal, 16 +/- 2 mU/min; following oral glucose, 13 +/- 2 U/...Continue Reading

References

Sep 1, 1976·The Journal of Clinical Endocrinology and Metabolism·W WaldhäuslP Nowotny
Mar 3, 1977·The New England Journal of Medicine·S W Shen, R Bressler
Apr 7, 1977·The New England Journal of Medicine·S W Shen, R Bressler
Feb 1, 1979·Diabetes·P Bratusch-MarrainJ Wahren
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·W WaldhäuslE Deutsch
Jun 21, 1976·European Journal of Clinical Investigation·E G Berger, P Moehr
Aug 1, 1968·Diabetes·A CzyzykZ Szczepanik
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Apr 1, 1963·Metabolism: Clinical and Experimental·G M GRODSKYP H FORSHAM

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Citations

Oct 1, 1985·Metabolism: Clinical and Experimental·H GinJ Aubertin
Jan 1, 1987·Diabetes/metabolism Reviews·W K Waldhäusl, P Bratusch-Marrain
Apr 1, 1987·Diabetes/metabolism Reviews·R A DeFronzo, E Ferrannini
Jul 1, 1983·Clinics in Endocrinology and Metabolism·R A Kreisberg, B C Wood
Feb 1, 1984·Metabolism: Clinical and Experimental·P R Bratusch-MarrainA Hofer
Jan 1, 1985·Annales Françaises D'anesthèsie Et De Rèanimation·S PoliC Perret
Jan 15, 1988·Biochemical Pharmacology·S D GettingsL J King

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