Effect of butylated hydroxyanisole on the level of DNA adduction by aristolochic acid in the rat forestomach and liver

Japanese Journal of Cancer Research : Gann
M N RoutledgeR C Garner

Abstract

Administration of butylated hydroxyanisole (BHA) orally at either 0.5 g or 1 g/kg daily for 14 days to rats did not produce any DNA adducts in the forestomach as measured by the 32P-postlabeling method using (1) limiting concentrations of 32P-ATP; (2) nuclease P1 enhancement; or (3) butanol extraction. Experiments were conducted to establish the effects of BHA administration on aristolochic acid (AA) DNA adduct formation in the forestomach and liver, when BHA was administered prior to, together with or after AA administration. Adduct levels per 10(9) nucleotides in the liver after oral dosing daily for 5 days with 1 mg/kg AA and BHA (1 g/kg) or corn oil (5 ml/kg) for 7 days were as follows: (a) BHA and AA given simultaneously; 235 +/- 71, (b) AA + corn oil; 63 +/- 39, (c) AA followed by BHA; 57 +/- 13, (d) AA followed by corn oil; 91 +/- 38, (e) BHA followed by AA; 90 +/- 12, (f) corn oil followed by AA; 83 +/- 24. For the forestomach the values were: (a) 236 +/- 86, (b) 77 +/- 25, (c) 367 +/- 97, (d) 296 +/- 47, (e) 217 +/- 81, (f) 70 +/- 64. These data suggest that BHA could have an enhancing effect on AA-induced lesions in the forestomach if dosed together with, or prior to, AA as adduct levels are significantly higher than ...Continue Reading

References

Sep 1, 1987·Mutagenesis·W P Watson
Feb 1, 1988·Carcinogenesis·H H SchmeiserM Wiessler
Aug 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H J AltmannC A van der Heijden
Oct 1, 1982·Mutation Research·G RobischW Göggelmann
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K RanderathR C Gupta

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Citations

Dec 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M WilliamsC Tong
Dec 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M WilliamsM J Iatropoulos
Aug 4, 2011·International Journal of Toxicology·F Alan AndersenPaul W Snyder

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