Effect of BW 942C, an enkephalinlike pentapeptide, on sodium and chloride transport in the rabbit ileum

Gastroenterology
H M BerschneiderD W Powell

Abstract

BW 942C is a novel enkephalinlike pentapeptide that has been shown to have antidiarrheal action in model systems. The effect of BW 942C on rabbit ileal electrolyte transport was studied to gain insight into the mechanism of the antidiarrheal action of opiate-like compounds. Multiple effects were observed, differing with the basal state of the tissue. BW 942C increased Na absorption in tissues that were not absorbing in the basal state, whereas it had little effect on Na absorption in tissues that were previously absorbing at moderate to high rates (greater than 1 microEq/h.cm2. It increased Cl absorption and caused a dose-related decrease in short-circuit current in all tissues. This effect was reversed or inhibited by naloxone (10(-5) M), suggesting that it is mediated by opiate receptors. No significant change in residual flux was noted. BW 942C was effective from both the serosal and mucosal side; however, it required a 2-log higher dose on the mucosal side (10(-4) M, maximal) to achieve a response similar to that observed with serosal application (10(-6) M, maximal). The ability of BW 942C to alter stimulated secretion was studied using theophylline, prostaglandin E2, vasoactive intestinal peptide, and bethanechol. There wa...Continue Reading

Citations

May 16, 2006·Digestive Diseases·Michael J G Farthing
Jan 26, 2000·Alimentary Pharmacology & Therapeutics·M P PrimiJ M Lecomte
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen

Related Concepts

2-Met-4-(4-nitro)-Phe-5-ProNH2-enkephalin
Metazoa
Antiperistaltic Agents
Chloride Ion Level
Dose-Response Relationship, Drug
Enkephalin, Methionine
Enkephalins
Ileum
Intestinal Absorption
Ion Channel

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