Effect of cabergoline, a long-acting dopamine D2 agonist, on reserpine-treated rodents

Biological & Pharmaceutical Bulletin
M MiyagiM Isaji

Abstract

We studied the characterization of cabergoline, a new ergot alkaloid derivative and a selective dopamine D2 receptor agonist, in comparison to bromocriptine and pergolide in reserpine-treated rodents. Cabergoline (0.25-1.0 mg/kg, s.c.) improved dose-dependently the reserpine-induced akinesia that was assessed on the locomotor activity, and the efficacy lasted longer than those of bromocriptine (1.25-5.0 mg/kg, s.c.) or pergolide (0.0625-0.5 mg/kg s.c.). Cabergoline (ED50 = 1.10 mg/kg, at 4 h after the administration of drugs) also reversed catalepsy, the failure to correct an externally imposed posture, and its efficacy was stronger and longer than bromocriptine (ED50 = 4.65 mg/kg, at 4 h). Further, reserpine-induced rigidity was improved equally by cabergoline (0.125-1.0 mg/kg, i.v) and bromocriptine (1.0 mg/kg, i.v.). When cabergoline was administered together with 3(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), the effects were additive. Our results indicate that the long-lasting effects of cabergoline could be beneficial for treating Parkinson's disease.

Citations

Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Dec 15, 2004·Neuroscience Research·Ken-ichi Tanaka, Norio Ogawa
Apr 28, 2004·Neurotoxicity Research·T NakagawaH Okamura
Jul 5, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·K Ichikawa, M Kojima

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