Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Vanesa Jiménez-OrtegaA I Esquifino

Abstract

The effect of cadmium (Cd) in the brain has been attributed to an increase in reactive oxygen species in cells, particularly when high amounts of the metal are given. In this study we examined the effect of a low dose of Cd (7.5 microg/day) on 24-h changes in expression of redox pathway enzyme and circadian genes in rat medial basal hypothalamus (MBH). Rats receiving CdCl(2) (5 ppm in drinking water) or tap water for 1 month were killed at six different time intervals throughout a 24 h cycle. MBH mRNA levels were measured by real-time PCR analysis. In CdCl(2) treated rats a disruption of 24-h pattern of hypothalamic gene expression of nitric oxide synthase (NOS)-1 and -2, heme oxygenase (HO)-1 and -2, Mn- superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase was detectable. Mean levels of MBH mRNA for HO-2, Mn-SOD and catalase augmented after Cd intake, whereas those of NOS-2 decreased. After CdCl(2) intake rats the 24-h pattern of clock gene expression in MBH seen in controls was significantly suppressed (Bmal1) or changed in phase (Per1, Per2, Cry2) while in the case of Clock significant 24-h variations were induced. The results are compatible with the view that a low amount of Cd given in tap...Continue Reading

References

Feb 16, 1987·Life Sciences·I WakabayashiK Nagai
Apr 6, 1968·Lancet·B James
Dec 22, 1999·Toxicology Letters·A Lafuente, A I Esquifino
Mar 11, 2000·Occupational and Environmental Medicine·M K ViaeneH A Roels
Mar 16, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M E InalE Sunal
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 25, 2002·Chronobiology International·Bahar TunçtanNurettin Abacioğlu
Jun 7, 2002·Toxicology·Eric B Harstad, Curtis D Klaassen
Dec 31, 2002·Toxicology Letters·Soisungwan SatarugMichael R Moore
Feb 27, 2003·Toxicology·M Luisa LeretM Teresa Antonio
Apr 1, 2003·Endocrine Research·Vanesa MartínCarmen Rodríguez
Dec 3, 2003·Neuroscience Letters·María Fernanda RubioDiego A Golombek
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter
Dec 19, 2003·Chronobiology International·Rüdiger HardelandBurkhard Poeggeler
Jun 4, 2004·Biological Research·Hans G RichterMaría Serón-Ferré
Jul 29, 2004·American Journal of Physiology. Renal Physiology·O BarbierM Cougnon
Sep 1, 2005·Toxicology and Applied Pharmacology·Malgorzata M Brzóska, Janina Moniuszko-Jakoniuk
Jan 21, 2006·Molecular and Cellular Biochemistry·Ahmet KoyuAhmet Kocak
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
May 2, 2006·Molecular and Cellular Endocrinology·Gerald A Lincoln
Oct 19, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mamane SaniBen Attia Mossadok
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Cesare MancusoVittorio Calabrese
Apr 14, 2007·Annual Review of Nutrition·Kathryn Moynihan RamseyJoseph Bass
May 8, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zhengqin YangJie Liu
Aug 7, 2007·International Review of Neurobiology·Ashley ReynoldsHoward E Gendelman
Nov 22, 2007·The Journal of Nutrition·Robert O Wright, Andrea Baccarelli
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zsolt RadakSataro Goto
Oct 14, 2008·Chemico-biological Interactions·Joanna RogalskaJanina Moniuszko-Jakoniuk
Jun 6, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Maja LazarusMaja Blanuša

❮ Previous
Next ❯

Citations

Mar 4, 2011·Neurotoxicity Research·Alejandro RomeroAnunciación Lafuente
Jul 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anunciación Lafuente
May 10, 2011·Biochemical and Biophysical Research Communications·Yeong-Su JangKiho Bae
Oct 28, 2016·Biochemical and Biophysical Research Communications·Bo XiaoYingbin Zhong
Jul 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zeynep Banu DoğanlarOğuzhan Doğanlar
Jul 14, 2018·Annals of Occupational and Environmental Medicine·Yu Min LeeEun-Hee Ha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.