Dec 1, 1982

Effect of caffeine on G2 repair and its reversion by adenosine

Mutation Research
A González-Fernández, J F López-Sáez


Chromosome damage induced in root meristems of Allium cepa L. by an 18-h treatment with 5-aminouracil (AU) was enhanced by 2-h pulses with 5 mM caffeine, the most effective pulse being given from the 8th to the 10th h after AU. Chromosome damage was detected by the percentage of anaphases or telophases showing chromosomal aberrations. This caffeine effect was partially reversed by adenosine. We suggest that this caffeine anti-repair effect could be due to a competition between methylxanthine and an adenine-nucleotide derivative (ATP?) required for some step(s) of G2-prophase repair.

Mentioned in this Paper

Base Excision Repair
Autosome Abnormalities
Cell Cycle
Adenosine Triphosphate, Chromium Ammonium Salt
Radiation-Sensitizing Effect

About this Paper

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