Effect of caffeine on ovariectomy-induced osteoporosis in rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Huanhuan XuJun Sheng

Abstract

Caffeine (1,3,7-trimethylxanthine) is a naturally occurring plant xanthine alkaloid present in many commonly consumed beverages worldwide, including tea, coffee, and cocoa. Although moderate caffeine intake is generally considered to exert positive effects on human health, its effect on bone metabolism remains controversial. The aim of this study was to systematically evaluate the pharmacological effect of long-term administration of caffeine on ovariectomy-induced postmenopausal osteoporosis in female rats. A sham operation or ovariectomy was performed to establish the ovariectomy rat model. The ovariectomized (OVX) rats were divided into five subgroups: OVX with vehicle (model), OVX with raloxifene hydrochloride (RLX, positive control; 4 mg/kg body weight/day), and OVX with low-, medium-, and high-dose caffeine (9.6, 19.2, and 38.4 mg/kg of body weight/day, respectively). Their corresponding treatments were administered intragastrically for 13 weeks. In-vivo studies showed that treatment with caffeine effectively improved the lipid profiles and increased the concentration of calcium in the serum of OVX rats. Medium- or high-dose treatment with caffeine significantly decreased the activities of alkaline and acid phosphatases i...Continue Reading

References

Mar 23, 1995·The New England Journal of Medicine·S R CummingsT M Vogt
Jan 26, 1994·JAMA : the Journal of the American Medical Association·E Barrett-ConnorS L Edelstein
Jul 1, 1997·Nutrition·B E Nordin
Aug 18, 1997·The American Journal of Medicine·C Cooper
Feb 15, 2002·Endocrine Reviews·Johannes PfeilschifterHelmut Schatz
May 16, 2003·Nature·William J BoyleDavid L Lacey
Oct 9, 2007·The American Journal of Clinical Nutrition·Amanda DevineRichard L Prince
Mar 19, 2008·Basic & Clinical Pharmacology & Toxicology·Jun-ichi OkanoYoshikazu Murawaki
Mar 3, 2009·Pharmacotherapy·Sheryl F VondracekMichael T McDermott
Mar 28, 2009·International Journal of Molecular Sciences·Pin-Zhen LuWen-Hsiung Chan
Feb 2, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shing Hwa LiuChingmin Tsai
Feb 7, 2013·British Journal of Clinical Pharmacology·Sandra Maria SaccoElizabeth Offord
Mar 26, 2013·Expert Opinion on Pharmacotherapy·Patrizia D'Amelio, Giovanni Carlo Isaia
Jun 12, 2013·Molecular Nutrition & Food Research·Joanna FolwarcznaLeszek Sliwiński
Nov 1, 2013·The American Journal of Clinical Nutrition·Chwan-Li ShenJia-Sheng Wang
May 20, 2014·Food & Function·Ye-wei HuangJun Sheng
Apr 2, 2015·Brazilian Dental Journal·Rander Moreira MacedoSuzie Aparecida de Lacerda
Jun 13, 2015·Critical Reviews in Food Science and Nutrition·Leslie A Nash, Wendy E Ward
Jul 1, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Chwan-Li Shen, Ming-Chien Chyu
Feb 9, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ozra Tabatabaei-MalazyBagher Larijani
Apr 26, 2017·Current Opinion in Psychiatry·Amy PeacockRaimondo Bruno
May 18, 2017·Nutrients·Li Tian, Xijie Yu
Dec 19, 2017·Human & Experimental Toxicology·M G HelalT M Ibrahim
Jan 31, 2018·The Journal of Nutrition, Health & Aging·H HuangS-M Xiao
Mar 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huanhuan XuJun Sheng
Apr 21, 2018·Frontiers in Immunology·Rupesh K SrivastavaPradyumna K Mishra
Jun 5, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gullanki Naga Venkata Charan Tej, Prasanta Kumar Nayak
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Titi LiuJun Sheng

❮ Previous
Next ❯

Citations

Oct 31, 2020·Frontiers in Cell and Developmental Biology·Huanhuan XuJun Sheng
Jan 26, 2021·Nutrition Reviews·Natalia Wawrzyniak, Joanna Suliburska
Jan 17, 2021·Nutrients·Alicja Ewa RatajczakIwona Krela-Kaźmierczak
Mar 24, 2021·Journal of Biochemical and Molecular Toxicology·Xiuhui WangZhe Wang
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhengping ZhangHonghui Sun
Aug 8, 2021·Journal of Periodontal Research·Omar OmarFaisal Al-Qarni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.