Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea

Pediatrics
J BauerRoland Hentschel

Abstract

Methylxanthines are among the most commonly prescribed drugs in neonatal intensive care. This study evaluates the effect of caffeine on oxygen consumption and metabolic rate in premature infants with idiopathic apnea. Eighteen preterm infants at gestational ages from 28 to 33 weeks and birth weights of 890 to 1680 g were enrolled in the study. Nine preterm infants received caffeine therapy, and 9 served as a control group. Oxygen consumption and energy expenditure were examined before, during, and after caffeine treatment. Oxygen consumption increased significantly from 7.0 +/- 0.9 before caffeine to 8.8 +/- 0.7 mL/kg/min after 48 hours of caffeine therapy, and energy expenditure increased from 2.1 +/- 0.3 to 3.0 +/- 0.2 kcal/kg/hour. During the observation period of 4 weeks of caffeine treatment, oxygen consumption increased significantly in the caffeine group compared with the control patients. In the caffeine group, a lower environmental temperature was sufficient to maintain a normal body temperature. With similar caloric intake in both groups during the study period, daily weight gain in the control group was significantly higher (21 +/- 4 vs 42 +/- 2 g/d). None of the other parameters recorded changed during caffeine ther...Continue Reading

Citations

Jul 22, 2005·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Laura A Stokowski
Mar 31, 2004·Seminars in Neonatology : SN·David Millar, Barbara Schmidt
Jun 5, 2003·Early Human Development·Jacqueline BauerOtwin Linderkamp
Feb 26, 2004·Paediatric Respiratory Reviews·Richard J MartinTerry M Baird
Sep 1, 2006·The New England Journal of Medicine·David M Coulter
May 19, 2006·The New England Journal of Medicine·Barbara SchmidtUNKNOWN Caffeine for Apnea of Prematurity Trial Group
Mar 26, 2003·The British Journal of Nutrition·Jacqueline BauerOtwin Linderkamp
Oct 2, 2007·Journal of the American College of Nutrition·Sharon LahatShaul Dollberg
May 23, 2006·The Journal of Perinatal & Neonatal Nursing·Shyang-Yun Pamela K Shiao
Jun 14, 2003·Current Opinion in Pediatrics·Jill FulhanChristopher Duggan
Jan 20, 2011·Journal of Paediatrics and Child Health·Peter H GrayUNKNOWN Caffeine Collaborative Study Group
Oct 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P SteerUNKNOWN Caffeine Collaborative Study Group Steering Group
Oct 6, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·C HoeckerO Linderkamp
Apr 9, 2008·Annual Review of Nutrition·Satish C Kalhan, Dennis M Bier
Aug 1, 2008·Journal of Child & Adolescent Substance Abuse·Christianne Esposito-SmythersAnthony Spirito
Dec 10, 2009·PLoS Computational Biology·Scott A SandsPhilip J Berger
Feb 23, 2007·Journal of Perinatal Medicine·Maria E L MoreiraJose M A Lopes
Mar 19, 2009·Journal of Perinatal Medicine·Jacqueline BauerGeorg Hoffmann
Mar 1, 2003·Paediatric Drugs·Varsha Bhatt-Mehta, Robert E Schumacher
Jan 9, 2014·Paediatric Drugs·Katherine SchoenCatherine M T Sherwin
Sep 16, 2014·Early Human Development·Eduardo Bancalari
Feb 1, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dalal TahaZubair H Aghai
Aug 28, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·W Moumen ChentoufB Meddah
Jul 31, 2012·Respiratory Physiology & Neurobiology·Peter M MacFarlaneRichard J Martin
Jun 23, 2012·Respiratory Physiology & Neurobiology·Aida BairamVincent Joseph
Sep 13, 2011·The Journal of Pediatrics·Ruben E AlvaroHenrique Rigatto
Jun 13, 2008·Brain Research·Amy M BlackJerome Y Yager
Dec 13, 2006·Seminars in Fetal & Neonatal Medicine·Christian V Hulzebos, Pieter J J Sauer
Jan 26, 2010·Acta Anaesthesiologica Scandinavica·T Rudolph, K Knudsen
Aug 22, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S DucrocqF Gold
Jul 29, 2015·Early Human Development·Vilhelmiina ParikkaHanna Soukka
Apr 15, 2016·Molecular and Cellular Pediatrics·Matthias C HüttenBoris W Kramer
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Susan J Carlson
Sep 13, 2003·The Journal of Pediatrics·Jacqueline BauerOtwin Linderkamp
Jan 21, 2017·International Journal of Molecular Sciences·Stefanie EndesfelderThomas Schmitz
Nov 14, 2015·World Journal of Clinical Pediatrics·Hesham Abdel-HadyIslam Nour
Dec 30, 2017·Journal of Neonatal-perinatal Medicine·S KhuranaL E S Lewis
Sep 7, 2017·Journal of Caffeine Research·Christa R TabacaruKaren D Fairchild

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