Effect of calcitonin on calcium transport by the luminal and basolateral membranes of the rabbit nephron

Kidney International
Q ZuoM G Brunette

Abstract

In the rabbit, calcitonin has been shown to enhance calcium (Ca2+) reabsorption in the early distal tubule. The aim of the present study was to investigate the mechanism of this action, using isolated luminal and basolateral membranes of distal tubules. The tubule suspensions were preincubated in the presence or absence of 10(-7) M calcitonin. The luminal or basolateral membranes were subsequently purified and 45Ca transport through the vesicles was measured using the rapid filtration technique. Results were compared with those obtained from proximal tubule membranes. In the proximal tubules, calcitonin had no effect on Ca2+ uptake by luminal membranes. In the distal tubules, the presence of Na+ in the incubation medium strongly decreased the uptake of Ca2+ by luminal membranes. Preincubation of distal tubules with calcitonin partially restored this uptake. We previously reported a dual kinetics of Ca2+ uptake by the distal luminal membranes. Calcitonin enhanced Ca2+ transport by the low affinity component, increasing the Vmax and leaving the K(m) unchanged. Renal calcitonin receptors usually couple to both adenylate cyclase and phospholipase C. To determine through which messenger(s) calcitonin enhances Ca2+ transport by the d...Continue Reading

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Citations

Oct 21, 1999·Journal of Cellular Physiology·M G BrunetteG Hilal
Sep 21, 2002·Molecular and Cellular Endocrinology·Michèle G Brunette, Marie Leclerc
Aug 4, 1999·Molecular and Cellular Endocrinology·M G BrunetteS Christakos
Sep 13, 2008·Clinical and Experimental Pharmacology & Physiology·Ramesh C Khanal, Ilka Nemere
Jun 18, 2004·Kidney International·Marie LeclercDenis Couchourel
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicole C KaneiderChristian J Wiedermann
Jan 1, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Christine Eckermann-Ross
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anne-Gaëlle LafontPung-Pung Hwang
Jul 14, 2004·Molecular and Cellular Endocrinology·Denis CouchourelMichèle G Brunette
Oct 30, 2016·International Journal of Molecular Sciences·Chia-Hao Lin, Pung-Pung Hwang
Mar 31, 2004·Canadian Journal of Physiology and Pharmacology·M G BrunetteY Bourgeois
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A CharbonneauM G Brunette
Mar 17, 2021·Cardiovascular Research·Martin AguilarSvetlana Reilly
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Vivek KumarJohn C Lieske

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