PMID: 3896580May 1, 1985Paper

Effect of calcitonin on gastrointestinal regulatory peptides in man

Clinical Endocrinology
J C StevensonS R Bloom

Abstract

A major physiological role of calcitonin in humans appears to be regulation of skeletal turnover. It has been suggested that another function of calcitonin is to prevent post-prandial rises in calcium, particularly in animals, but the importance of such a function in man remains to be determined. Although it is known that calcitonin has an inhibitory effect on the secretion of gastrin and insulin, its actions on other gut and pancreatic hormones have not previously been studied. To investigate interrelations between calcitonin and gastrointestinal regulatory peptides, 0.5 mg synthetic human calcitonin was administered to 10 fasting patients. No changes in the plasma concentrations of glucose, somatostatin, neurotensin, enteroglucagon, vasoactive intestinal polypeptide or bombesin were observed. In contrast, profound falls in the circulating levels of gastrin, insulin and pancreatic glucagon were seen, reaching a maximum shortly after the peak of plasma calcitonin concentration. Marked changes were also observed in the levels of motilin, pancreatic polypeptide and, to a lesser extent, gastric inhibitory polypeptide, but the maximal falls occurred about 40 min later, coinciding with a significant fall in serum calcium. It is poss...Continue Reading

References

Oct 13, 1979·Lancet·J C StevensonM I Whitehead
Jun 9, 1977·The New England Journal of Medicine·H J HirschK H Gabbay
Dec 1, 1978·The American Journal of Digestive Diseases·C OwyangV L Go
Aug 1, 1978·Metabolism: Clinical and Experimental·L CantalamessaM Peracchi
Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J FahrenkrugJ F Rehfeld
Jul 6, 1974·Lancet·C N MallinsonB Cox
Sep 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E LeichtK F Weinges
Oct 1, 1972·American Journal of Clinical Pathology·E M Gindler, J D King
Dec 1, 1973·The Journal of Clinical Investigation·T K GrayJ S Fordtran
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·T E AdrianS R Bloom
Jun 16, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·J DawsonT J Peters
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R V TalmageC J Vanderwiel
Feb 1, 1981·Postgraduate Medical Journal·J C StevensonB M Stevenson

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Citations

Nov 21, 1987·British Medical Journal·D Wynick, S R Bloom
Jan 1, 1995·Canadian Journal of Physiology and Pharmacology·H NakamuraK Takeda
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·G C Cook
Nov 21, 1987·British Medical Journal
Jan 1, 1987·Chronobiology International·B Tarquini, K J Vener

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