PMID: 3119687Dec 1, 1987Paper

Effect of calcium-binding additives on ventricular fibrillation and repolarization changes during coronary angiography

Journal of the American College of Cardiology
L S ZukermanP R Kowey


Ventricular fibrillation during coronary angiography with Renografin-76 (meglumine sodium diatrizoate) has been attributed to the calcium-binding additives sodium citrate and sodium ethylenediaminetetraacetic acid (EDTA), which may produce repolarization changes manifested as prolongation of the QT interval. Angiovist-370 is a newer form of meglumine sodium diatrizoate that contains calcium EDTA as its additive and thus has a decreased calcium-binding effect. Eight hundred sixteen patients were prospectively randomized to receive either Renografin-76 or Angiovist-370. Ventricular fibrillation occurred in 10 of 410 patients receiving Renografin-76 and in 0 of 406 patients given Angiovist-370 (p less than 0.0005). Clinical data were analyzed without knowledge of other data in the 10 patients treated with Renografin-76 who had ventricular fibrillation (Group I), 103 randomly selected patients who also received Renografin-76 but had no ventricular fibrillation (Group II) and 108 randomly selected patients given Angiovist-370 (Group III). Of several variables examined, only the QT interval differentiated patients receiving Renografin-76 and Angiovist-370. The mean corrected QT interval (QTc interval) before coronary angiography was ...Continue Reading


Sep 1, 1978·Investigative Radiology·H W Fischer, K R Thomson
Oct 1, 1978·Radiology·G L WolfK Kilzer
May 1, 1978·Investigative Radiology·K R ThomsonH W Fischer
Jul 1, 1975·Circulation·J B CaulfieldJ W Harthorne
May 1, 1986·Progress in Cardiovascular Diseases·P C HanleyH C Smith
Jul 1, 1987·Journal of Electrocardiology·J A ArrowoodP R Kowey
Feb 1, 1985·American Heart Journal·D K MurdockR M Gunnar
Mar 1, 1985·Journal of the American College of Cardiology·S Ahnve
Sep 1, 1973·Circulation·D F AdamsH L Abrams
Apr 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·A L SimonE C Lasser
Nov 1, 1971·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·C F SnyderK Amplatz
Jun 2, 1966·The New England Journal of Medicine·A Benchimol, E M McNally
Jan 1, 1970·The American Journal of Cardiology·N GootmanN M Buckley
Oct 1, 1966·Circulation·R N MacAlpinW N Hanafee
Jul 1, 1967·Circulation·R F SmithC A Sanders
Aug 1, 1984·Journal of the American College of Cardiology·B Surawicz, S B Knoebel
Sep 1, 1983·Pacing and Clinical Electrophysiology : PACE·M H LehmannH G Kemp
Jun 1, 1983·Journal of the American College of Cardiology·G L Wolf, J W Hirshfeld
Jan 1, 1982·Catheterization and Cardiovascular Diagnosis·J GwostE K Weir
Jan 1, 1964·Radiology·G G GENSINI, S DIGIORGI

❮ Previous
Next ❯


Aug 1, 1990·Catheterization and Cardiovascular Diagnosis·J W Hirshfeld
Feb 1, 1990·Journal of the American College of Cardiology·C L TalmanM L Marcus
Feb 23, 1992·The New England Journal of Medicine·J W Hirshfeld
Apr 14, 2004·Chest·Carlos Van MieghemDaniel Knockaert
Apr 1, 1991·The American Journal of Cardiology·E BrennanV J Aharonian
Feb 15, 1989·The American Journal of Cardiology·K G Lehmann, Y C Chen
Nov 28, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Enrique EsplugasFrancisco Jara

❮ Previous
Next ❯

Related Concepts

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.