PMID: 3119687Dec 1, 1987Paper

Effect of calcium-binding additives on ventricular fibrillation and repolarization changes during coronary angiography

Journal of the American College of Cardiology
L S ZukermanP R Kowey

Abstract

Ventricular fibrillation during coronary angiography with Renografin-76 (meglumine sodium diatrizoate) has been attributed to the calcium-binding additives sodium citrate and sodium ethylenediaminetetraacetic acid (EDTA), which may produce repolarization changes manifested as prolongation of the QT interval. Angiovist-370 is a newer form of meglumine sodium diatrizoate that contains calcium EDTA as its additive and thus has a decreased calcium-binding effect. Eight hundred sixteen patients were prospectively randomized to receive either Renografin-76 or Angiovist-370. Ventricular fibrillation occurred in 10 of 410 patients receiving Renografin-76 and in 0 of 406 patients given Angiovist-370 (p less than 0.0005). Clinical data were analyzed without knowledge of other data in the 10 patients treated with Renografin-76 who had ventricular fibrillation (Group I), 103 randomly selected patients who also received Renografin-76 but had no ventricular fibrillation (Group II) and 108 randomly selected patients given Angiovist-370 (Group III). Of several variables examined, only the QT interval differentiated patients receiving Renografin-76 and Angiovist-370. The mean corrected QT interval (QTc interval) before coronary angiography was ...Continue Reading

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Citations

Aug 1, 1990·Catheterization and Cardiovascular Diagnosis·J W Hirshfeld
Feb 1, 1990·Journal of the American College of Cardiology·C L TalmanM L Marcus
Feb 23, 1992·The New England Journal of Medicine·J W Hirshfeld
Apr 14, 2004·Chest·Carlos Van MieghemDaniel Knockaert
Apr 1, 1991·The American Journal of Cardiology·E BrennanV J Aharonian
Feb 15, 1989·The American Journal of Cardiology·K G Lehmann, Y C Chen
Nov 28, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Enrique EsplugasFrancisco Jara

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