Effect of calcium dobesilate on progression of early diabetic retinopathy: a randomised double-blind study

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Maria L RibeiroDX-Retinopathy Study Group

Abstract

The study was carried out to confirm the effect of calcium dobesilate (CaD) compared to placebo (PLA) on the blood-retinal barrier (BRB) permeability in early diabetic retinopathy (DR). Adults with type II diabetes and early diabetic retinopathy (below level 47 of ETDRS grading and PVPR between 20 and 50x10(-6)/ min, plasma-free fluorescein) were included in this double-blind placebo-controlled study. Treatment was 2 g daily for 24 months. The primary parameter, posterior vitreous penetration ratio (PVPR), was measured every 6 months by fluorophotometry. Secondary parameters were fundus photography, fluorescein angiography and safety assessments. Metabolic control was performed every 3 months. A total of 194 patients started the treatment (98 CaD, 96 PLA) and 137 completed the 24-month study (69 CaD, 68 PLA). Both treatment groups were comparable at baseline, with ETDRS level 10 in about 59% of patients. Mean PVPR change from baseline after 24 months was significantly (P=0.002) lower in the CaD group [-3.87 (SD 12.03)] than in the PLA group [+2.03 (SD 12.86)], corresponding to a 13.2% decrease in the CaD group and a 7.3% increase in the PLA group. PVPR evolution was also analysed by HbA1c classes (<7%, between 7 and 9%, > or =9...Continue Reading

References

Jan 1, 1977·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·I Salama BenarrochA Salama
Mar 1, 1990·International Ophthalmology·E B LeiteJ G Cunha-Vaz
Jan 1, 1985·Diabetes Care·P W RussellC Fetkenhour
Jan 1, 1974·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·H Freyler
Jan 1, 1984·American Journal of Ophthalmology·I J ConstableG C Grose
Jul 1, 1995·Klinische Monatsblätter für Augenheilkunde·A HaasK P Pfeiffer
Mar 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Cunha-VazJ R de Abreu
Apr 30, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Cunha-VazJ R de Abreu
May 5, 1998·Fundamental & Clinical Pharmacology·J BrunetP Hannaert
Oct 29, 2000·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J G Cunha-Vaz
Nov 4, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F J Snoek
Oct 25, 2001·European Journal of Pharmacology·M E SzaboR P Garay
Nov 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·C C Bailey, J M Sparrow
May 7, 2002·American Journal of Ophthalmology·Robert N Frank
Jul 26, 2002·Journal of Human Hypertension·A K Sjølie, N Chaturvedi
Sep 14, 2002·Endocrinology and Metabolism Clinics of North America·Karla BergerhoffBernd Richter
Dec 17, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·C Alex Harper
Feb 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Nish ChaturvediUNKNOWN DIRECT Programme Study Group
Jul 23, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·R E GilbertD J Kelly
Oct 9, 2003·JAMA : the Journal of the American Medical Association·K M Venkat NarayanDavid F Williamson
Jul 14, 2004·European Journal of Pharmacology·Rossella RotaPatrick Hannaert
Aug 2, 2005·Treatments in Endocrinology·Ricardo P GarayCarlo Chiavaroli

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Citations

Mar 8, 2013·Future Medicinal Chemistry·Megha BarotAshim K Mitra
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Alex PollockUma Shahani
Nov 25, 2017·Neural Regeneration Research·Olga Simó-ServatRafael Simó
Dec 22, 2014·Science China. Life Sciences·XinYuan ZhangNingLi Wang
Mar 31, 2017·Journal of Endocrinological Investigation·C HernándezR Simó
Dec 29, 2007·Current Opinion in Ophthalmology
Aug 29, 2021·Pharmaceutics·Rafael SimóCristina Hernández
Feb 16, 2019·Life Sciences·Jie LiuDong Sun

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