Effect of Calcium Precursor on the Bioactivity and Biocompatibility of Sol-Gel-Derived Glasses

Journal of Functional Biomaterials
Alejandra Ruiz-ClavijoNichola J Coleman

Abstract

This study investigated the impact of different calcium reagents on the morphology, composition, bioactivity and biocompatibility of two-component (CaO-SiO₂) glasses produced by the Stöber process with respect to their potential application in guided tissue regeneration (GTR) membranes for periodontal repair. The properties of the binary glasses were compared with those of pure silica Stöber particles. The direct addition of calcium chloride (CC), calcium nitrate (CN), calcium methoxide (CM) or calcium ethoxide (CE) at 5 mol % with respect to tetraethyl orthosilicate in the reagent mixture gave rise to textured, micron-sized aggregates rather than monodispersed ~500 nm spheres obtained from the pure silica Stöber synthesis. The broadening of the Si-O-Si band at ~1100 cm-1 in the infrared spectra of the calcium-doped glasses indicated that the silicate network was depolymerised by the incorporation of Ca2+ ions and energy dispersive X-ray analysis revealed that, in all cases, the Ca:Si ratios were significantly lower than the nominal value of 0.05. The distribution of Ca2+ ions was also found to be highly inhomogeneous in the methoxide-derived glass. All samples released soluble silica species on exposure to simulated body fluid...Continue Reading

References

Jan 1, 1994·Journal of Biomedical Materials Research·P LiK de Groot
Feb 27, 2004·Journal of Biomedical Materials Research. Part a·J E GoughL L Hench
Feb 2, 2006·Biomaterials·Tadashi Kokubo, Hiroaki Takadama
Nov 26, 2008·Biomaterials·Eun-Jung LeeJun-Hyeog Jang
Oct 5, 2011·International Journal of Biological Macromolecules·Soumitri PattnaikNagarajan Selvamurugan
Apr 14, 2012·Journal of Tissue Engineering and Regenerative Medicine·Sandhra M CarvalhoMarivalda M Pereira
Nov 23, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Bobo YuJulian R Jones
Mar 28, 2013·Journal of Biomedical Materials Research. Part a·Michelina CatauroFerdinando Papale
Dec 4, 2013·International Journal of Biological Macromolecules·A P HurtN J Coleman
Jan 21, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Xiaojing LiYan Dong
May 15, 2015·Acta Biomaterialia·Saad B QasimIhtesham Ur Rehman
Feb 19, 2016·Journal of Colloid and Interface Science·Sarah L GreasleyJulian R Jones
May 6, 2017·Advances in Colloid and Interface Science·Roudayna DiabAndreea Pasc
Jul 30, 2017·Journal of Functional Biomaterials·Fabiola Vaca-CornejoJudith M Dueñas Jiménez
Sep 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Sedef Tamburaci, Funda Tihminlioglu
Jul 6, 2010·Materials·Lutz-Christian Gerhardt, Aldo R Boccaccini
Feb 7, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Antonio G B CastroFang Yang
Mar 17, 2018·Journal of Functional Biomaterials·Elisa FiumeFrancesco Baino
May 4, 2018·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·R RiccòF Enrichi
Jun 2, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Shiva Soltani DehnaviShahin Bonakdar
Aug 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·M Clara Gonçalves
Nov 11, 2018·Journal of Functional Biomaterials·Gianluca TurcoRoberto Di Lenarda
Nov 18, 2018·Cell Biology International·Susanne StaehlkeBarbara Nebe
Jan 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Emad TolbaXiaohong Wang

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Methods Mentioned

BETA
X-ray
scanning electron microscopy
thermal treatment
NMR

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