PMID: 8601931Apr 10, 1996Paper

Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials

JAMA : the Journal of the American Medical Association
H C BucherD L Hunt

Abstract

To review the effect of calcium supplementation during pregnancy on blood pressure, preeclampsia, and adverse outcomes of pregnancy. We searched MEDLINE and EMBASE for 1966 to May 1994. We contacted authors of eligible trials to ensure accuracy and completeness of data and to identify unpublished trials. Fourteen randomized trials involving 2459 women were eligible. Reviewers working independently in pairs abstracted data and assessed validity according to six quality criteria. Each trial yielded differences in blood pressure change between calcium supplementation and control groups that we weighted by the inverse of the variance. The pooled analysis showed a reduction in systolic blood pressure of -5.40 mm Hg (95% confidence interval [CI], -7.81 to -3.00 mm Hg; P<.001) and in diastolic blood pressure of -3.44 mm Hg (95% CI, -5.20 to -1.68 mm Hg; P<.001). The odds ratio for preeclampsia in women with calcium supplementation compared with placebo was 0.38 (95% CI, 0.22 to 0.65). Calcium supplementation during pregnancy leads to an important reduction in systolic and diastolic blood pressure and preeclampsia. While pregnant women at risk of preeclampsia should consider taking calcium, many more patient events are needed to confir...Continue Reading

Citations

Jan 24, 1998·Lancet·J LauC H Schmid
Dec 24, 2005·Journal of Women's Health·Robert P Heaney, Gloria A Bachmann
Mar 21, 1998·Cardiology Clinics·D Perloff
May 3, 2001·Environmental Health Perspectives·B L GulsonA J Taylor
Feb 27, 2009·The American Journal of Clinical Nutrition·Mei ChungJoseph Lau
Jul 16, 2009·Reproductive Biology and Endocrinology : RB&E·Simon GrillOlav Lapaire
Mar 16, 2013·Advances in Nutrition·Robert P Heaney
Nov 13, 2013·BMC Pregnancy and Childbirth·Erika Barbosa CamargoMaria Regina Torloni
Jul 1, 1997·Biological Trace Element Research·H F Loyke
Aug 25, 2001·Paediatric and Perinatal Epidemiology·R B JohnstonD R Mattison
Jun 30, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S NiromaneshA Mosavi-Jarrahi
Jan 1, 1997·Annual Review of Medicine·A G Witlin, B M Sibai
Oct 20, 2009·Nutrition Research Reviews·Viviana CentenoNori Tolosa de Talamoni
Jul 10, 1997·The New England Journal of Medicine·J M Roberts
Jul 10, 1997·The New England Journal of Medicine·R J LevineJ A Cutler
Jul 31, 1998·The New England Journal of Medicine·R L Goldenberg, D J Rouse
Jan 1, 1997·Pharmacology & Therapeutics·S M KhedunB Maharaj
Feb 6, 2010·Archives of Gynecology and Obstetrics·Thorkild F Nielsen, Ragnar Rylander
Oct 12, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M Bukar, A Idrisa
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·B BassawH Homer
Jul 17, 1998·Annals of Medicine·M L NurminenH Vapaatalo
Nov 5, 1997·Kidney International·P Jungers, D Chauveau
May 26, 2009·Journal of the American Dietetic Association·Sheryl L Rifas-ShimanMatthew W Gillman
Jun 15, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·G J HofmeyrA Atallah
May 17, 2001·Journal of Manipulative and Physiological Therapeutics·G Goodman, T R Jones
Jan 20, 2006·Paediatric and Perinatal Epidemiology·Sheryl L Rifas-ShimanMatthew W Gillman
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Nigel M PagePhilip J Lowry
Dec 22, 1999·American Journal of Obstetrics and Gynecology·M L PowerJ Schulkin
Jan 20, 2012·Orvosi hetilap·Andrea FodorTamás Major
Jun 16, 1999·American Journal of Obstetrics and Gynecology·V R SuárezJ G Trelles
Feb 22, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Adam C Urato, Errol R Norwitz
Jul 31, 2013·Journal of Reproductive Immunology·James M Roberts, Mandy J Bell
Aug 1, 2012·Journal of Pregnancy·Elosha EilandMarquetta Faulkner
Aug 15, 2000·Annual Review of Nutrition·A Prentice
Oct 3, 2018·The Cochrane Database of Systematic Reviews·G Justus HofmeyrMaria Regina Torloni
Aug 19, 1999·Clinical Obstetrics and Gynecology·E R NorwitzJ T Repke
Feb 1, 1997·Obstetrical & Gynecological Survey·M GülmezogluJ Villar
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·J R Higgins, S P Brennecke
Feb 16, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R KulierJ Villar
May 9, 2000·The American Journal of Clinical Nutrition·L D Ritchie, J C King
Oct 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P López-JaramilloN Serrano
Oct 16, 2003·Journal of the American College of Nutrition·Theresa A Nicklas
Oct 27, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·José Geraldo Lopes RamosClarissa Carvalho
Jun 25, 2014·The Cochrane Database of Systematic Reviews·G Justus HofmeyrMaria R Torloni

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