Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques

Annals of the New York Academy of Sciences
Henryk F UrbanskiD K Ingram

Abstract

Although dietary caloric restriction (CR) can retard aging in laboratory rats and mice, it is unclear whether CR can exert similar effects in long-lived species, such as primates. Therefore, we tested the effect of CR on plasma levels of dehydroepiandrosterone sulfate (DHEAS), a reliable endocrine marker of aging. The study included six young (approximately 10 years) and ten old (approximately 25 years) male rhesus macaques, approximately half of the animals in each age group having undergone >4 years of 30% CR. Hourly blood samples were collected remotely for 24 hours, through a vascular catheter, and assayed for DHEAS and cortisol. Both of these adrenal steroids showed a pronounced diurnal plasma pattern, with peaks occurring in late morning, but only DHEAS showed an aging-related decline. More importantly, there was no significant difference in plasma DHEAS concentrations between the CR animals and age-matched controls. These data fail to support the hypothesis that CR can attenuate the aging-related decline in plasma DHEAS concentrations, at least not when initiated after puberty.

References

Sep 1, 1990·Journal of Gerontology·D K IngramB M Marriott
Nov 1, 1993·Neurobiology of Aging·D K IngramG S Roth
Jul 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M A LaneG S Roth
Oct 2, 1997·The New England Journal of Medicine·R Weindruch, R S Sohal
Jun 1, 2000·Experimental Gerontology·E J Masoro
Dec 13, 2000·Experimental Gerontology·J J RamseyR Weindruch
Jan 25, 2002·Annals of the New York Academy of Sciences·M A LaneG S Roth

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Citations

Aug 28, 2009·Age·Krystina G Sorwell, Henryk F Urbanski
Dec 27, 2011·Age·Henryk F Urbanski, Krystina G Sorwell
Jun 4, 2010·Antioxidants & Redox Signaling·Leanne M Redman, Eric Ravussin
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Christopher A Jolly
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Rao ZhouDavid H Abbott
Jun 12, 2013·General and Comparative Endocrinology·Rafaela Sayuri Cicalise TakeshitaKeiko Shimizu
Feb 16, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Luigi Fontana
Mar 11, 2006·Médecine sciences : M/S·Martine Perret, Fabienne Aujard

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